When doctors prescribe books to heal the mind

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By Leah Price

More than 350 million people worldwide suffer from depression. Fewer than half receive any treatment; even fewer have access to psychotherapy. Around the turn of the millennium, antidepressants became the most prescribed kind of drug in the United States. In the United Kingdom, 1 in 6 adults has taken one.

But what if a scientist were to discover a treatment that required minimal time and training to administer, and didn’t have the side effects of drugs? In 2003, a psychiatrist in Wales became convinced that he had. Dr. Neil Frude noticed that some patients, frustrated by year-long waits for treatment, were reading up on depression in the meantime. And of the more than 100,000 self-help books in print, a handful often seemed to work.

This June, a program was launched that’s allowing National Health Service doctors across England to act upon Frude’s insight. The twist is that the books are not just being recommended, they’re being “prescribed.” If your primary care physician diagnoses you with “mild to moderate” depression, one of her options is now to scribble a title on a prescription pad. You take the torn-off sheet not to the pharmacy but to your local library, where it can be exchanged for a copy of “Overcoming Depression,” “Mind Over Mood,” or “The Feeling Good Handbook.” And depression is only one of over a dozen conditions treated. Other titles endorsed by the program include “Break Free from OCD,” “Feel the Fear and Do it Anyway,” “Getting Better Bit(e) by Bit(e),” and “How to Stop Worrying.”

The NHS’s Books on Prescription program is only the highest-profile example of a broader boom in “bibliotherapy.” The word is everywhere in Britain this year, although—or because—it means different things to different people. In London, a painter, a poet, and a former bookstore manager have teamed up to offer over-the-counter “bibliotherapy consultations”: after being quizzed about their literary tastes and personal problems, the worried well-heeled pay 80 pounds for a customized reading list. At the Reading Agency, a charity that developed and administers Books on Prescription, a second program called Mood-Boosting Books recommends fiction and poetry. The NHS’s public health and mental health budgets also fund nonprofits such as The Reader Organization, which gathers people who are unemployed, imprisoned, old, or just lonely to read poems and fiction aloud to one another.

At best, Books on Prescription looks like a win-win for both patients and book lovers. It boosts mental health while also bringing new library users in the door. Libraries loaned out NHS-approved self-help books 100,000 times in the first three months of the program; no doubt some of their borrowers must have picked up a novel or a memoir en route to the circulation desk. At worst, it’s hard to see what harm the program can do. Unlike drugs, books carry no risk of side effects like weight gain, dampened libido, or nausea (unless you read in the car).

For book lovers, an organization with as much clout as the NHS would seem to be a welcome ally. Yet its initiatives raise troubling questions about why exactly a society should value reading. What’s lost when a bookshelf is repurposed as a medicine cabinet—and when a therapist’s job gets outsourced to the page?

In 1916, the clergyman Samuel Crothers coined the term “bibliotherapy,” positing tongue-in-cheek that “a book may be a stimulant or a sedative or an irritant or a soporific.” In the intervening century, doctors, nurses, librarians, and social workers have more seriously championed “bibliopathy,” “bibliocounseling,” “biblioguidance,” and “literatherapy”—all variations on the notion that reading can heal.

Only recently, however, have the mental health effects of one genre—self-help books—been rigorously studied. As early as 1997, a randomized trial found bibliotherapy supervised by therapists no less effective in treating unipolar depression than individual or group therapy. More surprisingly, a 2007 literature review by the same researcher found that books treated anxiety just as effectively without a therapist’s guidance as with it. A 2004 meta-analysis comparing bibliotherapy for anxiety and depression to short-term talk therapy found books “as effective as professional treatment of relatively short duration.”

None of this means a book can outperform a therapist, even if it can underbid him. A 2012 meta-analysis of anxiety disorders concluding that “comparing self-help with waiting list gave a significant effect size of 0.84 in favour of self-help” nevertheless cautioned that “comparison of self-help with therapist-administered treatments revealed a significant difference in favour of the latter.” Translation: A book does worse than a therapist, but it’s better than nothing. And in the short term, at least, nothing is what many patients get.

Books on Prescription can be understood as an extension of larger changes in psychiatry over the past few decades. For most of the 20th century, psychodynamic therapy placed more emphasis on the therapist-patient relationship than on the content of the therapist’s words. More recently, insurers’ interest in cutting costs and researchers’ interest in protocols that can be measured and replicated have combined to nudge treatment toward short-term, standardized methods such as cognitive-behavioral therapy. Books take this trajectory to its logical conclusion. If your aim is less to help patients explore the underlying causes of their condition than to offer step-by-step instructions for managing it, then who cares whether the exercises emanate from a mouth, a manual, or even a smartphone app?

But even therapies like cognitive-behavioral therapy require the patient to feel recognized and understood by another human being. Asked how a printed page can mimic that face-to-face encounter, Frude comes up with an unexpected word: “magic.” The best books give the illusion of listening and caring, he explains, because authors who are also clinicians can draw on years of experience interacting with patients to leave each reader saying “that book was about me.” He does acknowledge that not every case fits books “off the peg” (or off the rack, as we say in the United States). But it’s a striking metaphor to choose—one that makes psychodynamic therapy sound like a luxury good as unattainable as Savile Row tailoring.

Where Frude sees magic, a cynic might smell pragmatism. Even short-term cognitive-behavioral therapy costs more than a $24.95 hardcover. But in any case, many patients read whether or not they have the NHS’s blessing. If recommended titles crowd out the misinformation that patients might otherwise stumble upon, whether in print or online, Books on Prescription will already have helped.

It’s hard not to notice that Books on Prescription was developed in the same years when American universities began to offer MOOCs, or massive open online courses. Even if an online course lacks the give-and-take of a seminar, it’s better than nothing. Like Books on Prescription, MOOCs scale up an activity whose face-to-face version was traditionally out of reach of the masses. Also like Books on Prescription, MOOCs create a cost-effective alternative that may eventually squeeze out personal contact even at the high end of the market.

That concern aside, it’s no surprise that self-help books can help the self. That literature might help, however, is a more controversial proposition. The other half of the Reading Agency’s two-pronged Reading Well initiative, Mood-Boosting Books, promotes fiction, poetry, and memoirs. Its annual list of “good reads for people who are anxious or depressed” mixes titles that represent characters experiencing anxiety or depression (Mark Haddon’s “A Spot of Bother”) with others calculated to combat those conditions. Some go for laughs (Sue Townsend’s “The Secret Diary of Adrian Mole Aged 13¾”); others, such as “A Street Cat Named Bob” and “The Bad Dog’s Diary,” read like printouts of PetTube.com. Others are darker and more demanding: Reading Well anointed Alice Munro’s short stories as a selection before the Nobel Prize Committee did.

The Reading Agency’s endorsement of imaginative reading stops short of recommending specific titles. Its website bristles with disclaimers that the works of literature are nominated by reading groups rather than tested by scientists. Yet the charity has given Mood-Boosting Books prestige—and the NHS has put hard cash behind them as well, providing some libraries with grants to purchase the recommended works of literature along with the “prescribed” self-help titles.

I ask Judith Shipman, who runs the Mood-Boosting Books program, whether recommending books “for people who are anxious or depressed” implies that poems or novels can treat those conditions. “I don’t think we could claim that they are therapy or a substitute for therapy,” she hazards after a long pause. “But for those who don’t quite need therapy, Mood-Boosting Books could be a nice little lift.”

Today it might seem commonplace to suggest that books are good for you. In the longer view, though, the hope that both literature and practical nonfiction can cure reverses an older belief by doctors that reading could cause physical and mental illness. In 1867, one expert cautioned that taking a book to bed could “injure your eyes, your brain, your nervous system.” Some social reformers proposed regulating books as if they were drugs. In 1883, the New York State Legislature debated whether to fine “any person who shall sell, loan, or give to any minor under sixteen years of age any dime novel or book of fiction, without first obtaining the written consent of the parent or guardian of such a minor.” As late as 1889, one politician called fiction “moral poison.”

As radio, TV, gaming, and eventually the Internet began to compete with books, though, fiction-reading came to look wholesome by comparison. Today, with only half of Americans reading any book for pleasure in a given year, reading is finding new champions from an unlikely quarter: science. This year, Science published a study concluding that reading about fictional characters increases empathy; in his 2011 book “The Better Angels of Our Nature,” the psychologist Steven Pinker correlated the rise of imaginative literature with a centuries-long decline in violence. And while correlation doesn’t imply causation, randomized trials have also attempted to link fiction-reading to physical health. In a 2008 study of 81 preteens, girls assigned fiction in which characters eat balanced breakfasts ended up with a lower body mass index than the control group. The Reading Well website itself cites a 2009 study that compared heart rates and muscle tension before and after various activities and found that reading is “68% better at reducing stress levels than listening to music; 100% more effective than drinking a cup of tea.” The numbers may be less telling than the fact that someone would think to compare books to tea in the first place.

It’s too early to predict the long-term effects of bibliotherapy programs. There’s little precedent for a government to make neuroscientists and psychiatrists the arbiters of what books should be read and why. And literary critics like me recoil from reducing the value of reading to a set of health metrics. But as library budgets shrink and any text longer than 140 characters gets crowded out by audio and video, white-coated experts may be the only ones prospective readers can hear. Racing to find out what happens next, seeing the world through a character’s eyes, wallowing in the play of language—all are becoming means to medical ends. Today, for an increasing number of people, the pleasures of reading require a doctor’s note.

http://www.bostonglobe.com/ideas/2013/12/22/when-doctors-prescribe-books-heal-mind/H2mbhLnTJ3Gy96BS8TUgiL/story.html

More evidence that mindfullness meditation can help with anxiety, depression and pain

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By Andrew M. Seaman

Mindfulness meditation may be useful in battles against anxiety, depression and pain, according to a fresh look at past research.

Using data from 47 earlier studies, researchers found moderate evidence to support the use of mindfulness meditation to treat those conditions. Meditation didn’t seem to affect mood, sleep or substance use.

“Many people have the idea that meditation means just sitting quietly and doing nothing,” wrote Dr. Madhav Goyal in an email to Reuters Health. “That is not true. It is an active training of the mind to increase awareness, and different meditation programs approach this in different ways.”

Goyal led the study at The Johns Hopkins University in Baltimore.

He and his colleagues write in JAMA Internal Medicine that meditation techniques emphasize mindfulness and concentration.

So-called mindfulness meditation is aimed at allowing the mind to pay attention to whatever thoughts enter it, such as sounds in the environment, without becoming too focused. Mantra meditation, on the other hand, involves focusing concentration on a particular word or sound.

Approximately 9 percent of people in the U.S. reported meditating in 2007, according to the National Institutes of Health. About 1 percent said they use meditation as some sort of treatment or medicine.

For the new report, the researchers searched several electronic databases that catalog medical research for trials that randomly assigned people with a certain condition – such as anxiety, pain or depression – to do meditation or another activity. These randomized controlled trials are considered the gold standard of medical research.

The researchers found 47 studies with over 3,500 participants that met their criteria.

After combining the data, Goyal said his team found between a 5 and 10 percent improvement in anxiety symptoms among people who took part in mindfulness meditation, compared to those who did another activity.

There was also about a 10 to 20 percent improvement in symptoms of depression among those who practiced mindfulness meditation, compared to the other group.

“This is similar to the effects that other studies have found for the use of antidepressants in similar populations,” Goyal said.

Mindfulness meditation was also tied to reduced pain. But Goyal said it’s hard to know what kind of pain may be most affected by meditation.

The benefits of meditation didn’t surpass what is typically associated with other treatments, such as drugs and exercise, for those conditions.

“As with many therapies, we try to get a moderate level of confidence that the therapy works before we prescribe it,” Goyal said. “If we have a high level of confidence, it is much better.”

But he noted that the researchers didn’t find anything more than moderate evidence of benefit from meditation for anxiety, depression and pain.

There was some suggestion that meditation may help improve stress and overall mental health, but the evidence supporting those findings was of low quality.

There was no clear evidence that meditation could influence positive mood, attention, substance use, eating habits, sleep or weight.

“Clinicians should be prepared to talk with their patients about the role that meditation programs could have in addressing psychological stress, particularly when symptoms are mild,” Goyal said.

Dr. Allan Goroll, who wrote an editorial accompanying the new study, told Reuters Health the analysis is an example of an area of much-needed scientific study, because many people make treatment decisions based on beliefs – not data.

“That is particularly the case with alternative and complimentary approaches to treating medical problems,” he said. “It ranges from taking vitamins to undergoing particular procedures for which the scientific evidence is very slim but people’s beliefs are very great.”

Goroll is professor at Harvard Medical School and Massachusetts General Hospital in Boston.

Goyal said people should remember that meditation was not conceived to treat any particular health problem.

“Rather, it is a path we travel on to increase our awareness and gain insight into our lives,” he wrote. “The best reason to meditate is to gain this insight. Improvements in health conditions are really a side benefit, and it’s best to think of them that way.”

SOURCE: bit.ly/WiwDtv JAMA Internal Medicine, online January 6, 2014.

Japanese turnip may stop the flu

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Scientists have discovered that bacteria found in a traditional Japanese pickle can prevent flu. Could this be the next superfood?

The research, which assesses the immune-boosting powers of Lactobacillus brevis from Suguki – a pickled turnip, popular in Japan – in mice that have been exposed to a flu virus, is published today (06 November) in the SfAM journal, Letters in Applied Microbiology.

Lead researcher, Ms Naoko Waki of KAGOME CO., LTD. in Japan said: “Our results show that when a particular strain of Lactobacillus brevis is eaten by mice, it has protective effects against influenza virus infection.”

Suguki enthusiasts have often cited its protective powers but it is not known yet whether the same effects will be seen in humans. Human clinical trials using a probiotic drink containing Lactobacillus brevis KB290 bacteria are underway and scientists are hopeful that, given a suitable quantity of bacteria, foods containing them may turn out to be the next superfood.

What it is about the bacteria that gives them this amazing property is not known, but it is remarkably tolerant to stomach juices, which are too acidic for many bacteria. This is largely due to a protective layer of sugars called exopolysaccharides.

“We know that exopolysaccharides have immune boosting effects in other similar bacteria, so we wonder if the exopolysaccharides of KB290 are responsible for the effects we see,” said Ms Waki. Further studies will be undertaken to investigate this.

The effect of the bacteria is to increase the production of immune system molecules in the body – IFN-α and flu-specific antibodies – and to enhance activity to eradicate virus infected cells. In this study these effects were sufficient to prevent infection by the H1N1 flu and the scientists think that there could also be protection against other viral infections, including the deadly H7N9 flu, which has recently emerged in China.

http://www.eurekalert.org/pub_releases/2013-11/w-jsp110413.php

More Than 300 Sharks In Australia Are Now On Twitter

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By Alan Yu

Sharks in Western Australia are now tweeting out where they are.

Government researchers have tagged 338 sharks with acoustic transmitters that monitor where the animals are. When a tagged shark is about half a mile away from a beach, it triggers a computer alert, which tweets out a message on the Surf Life Saving Western Australia Twitter feed. The tweet notes the shark’s size, breed and approximate location.

Since 2011, Australia has had more fatal shark attacks than any other country; there have been six over the past two years — the most recent in November.

The tagging system alerts beachgoers far quicker than traditional warnings, says Chris Peck, operations manager of Surf Life Saving Western Australia. “Now it’s instant information,” he tells Sky News, “and really people don’t have an excuse to say we’re not getting the information. It’s about whether you are searching for it and finding it.”

The tags will also be monitored by scientists studying the sharks. Researchers have tagged great whites, whaler sharks and tiger sharks.

“This kind of innovative thinking is exactly what we need more of when it comes to finding solutions to human-wildlife conflict,” says Alison Kock, research manager of the Shark Spotters program in South Africa. Kock tells NPR that the project is a good idea — but that people should know that not all sharks are tagged.

Her program does the same work, but humans do the spotting and tweeting.

Kock and Kim Holland, a marine biologist who leads shark research at the University of Hawaii, agree that the tweets won’t be enough to protect swimmers.

“It can, in fact, provide a false sense of security — that is, if there is no tweet, then there is no danger — and that simply is not a reasonable interpretation,” Holland says, pointing out that the reverse is also true. “Just because there’s a shark nearby doesn’t mean to say that there’s any danger. In Hawaii, tiger sharks are all around our coastlines all the time, and yet we have very, very few attacks.”

In Western Australia, the local government recently proposed a plan to bait and kill sharks that swim near beaches.

Holland says most shark biologists would agree that’s not a good plan, partly because of what researchers have learned using acoustic transmitters. Scientists tracking white sharks, for example, found that the species can travel great distances, going from Western Australia to South Africa in some cases.

“Because we know that they are so mobile, we’re not sure that killing any of them will have any effect on safety,” Holland says, pointing out that great white sharks don’t set up shop along the same coastlines for long. He says the number of these sharks is on the rise — but there aren’t that many to begin with.

“The other side of the coin is that it’s a horrible thing to see when people get killed, so there’s often public outcry for government agencies to do something.”

http://www.npr.org/blogs/alltechconsidered/2013/12/31/258670211/more-than-300-sharks-in-australia-are-now-on-twitter?ft=1&f=1001

Jet pilot reports near miss with UFO 20 miles west of Heathrow airport

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By Jasper Copping

An airline pilot has reported a near miss in which a “rugby ball”-shaped UFO passed within a few feet of his passenger jet while flying near Heathrow Airport.

The captain told the aviation authorities who have investigated the incident that he was certain the object was going to crash into his aircraft and ducked as it headed towards him.

The investigation has been unable to establish any earthly identity for the mysterious craft, which left the aircrew with no time to take evasive action.

The incident occurred while the A320 Airbus was cruising at 34,000ft, around 20 miles west of the airport, over the Berkshire countryside.

The captain spotted the object travelling towards the jet out of a left hand side, cockpit window, apparently heading directly for it.

A report into the incident states: “He was under the apprehension that they were on collision course with no time to react. His immediate reaction was to duck to the right and reach over to alert the FO (First Officer); there was no time to talk to alert him.”

It adds: “The Captain was fully expecting to experience some kind of impact with a conflicting aircraft.”

He told investigators he believes the object passes “within a few feet” above the jet.

He described it as being “cigar/rugby ball like” in shape, bright silver and apparently “metallic” in construction.

Once he had composed himself, he checked the aircraft’s instruments and contacted air traffic controllers to report the incident. However, there was no sign of the mystery craft.

The incident was investigated by the UK Airprox Board, which studies “near misses” involving aircraft in British airspace.

It checked data recordings to establish what other aircraft were in the area at the time, but eliminated them all from its quest to find out what had been responsible. It also ruled out meteorological balloons, after checking none were released in the vicinity. Toy balloons were also discounted, as they are not large enough to reach such heights. Military radar operators were also contacted but were unable to trace the reported object.

The sighting occurred in daylight, at around. 6.35pm on July 13. It has only emerged now, following publication of the report, which concluded it was “not possible to trace the object or determine the likely cause of the sighting”.

The report does not name the airline or flight involved. Even though it describes the aircraft as being “just to the west of Heathrow”, aviation experts believe that at such an altitude it would be unlikely to have taken off from, or be preparing to land at, the west London airport.

Instead, the A320, which is popular with many carriers, among them British Airways and Virgin, is likely to have been travelling between a regional airport elsewhere in the UK, and another on the Continent. The aircraft typically carry about 150 passengers.

The Ministry of Defence closed its UFO desk in December 2009, along with its hotline for reporting such sightings. Following that change, the Civil Aviation Authority took the decision that it would continue to look into such reports, from aircrew and air traffic controllers, because they could have implications for “flight safety”.

In 2012, the head of the National Air Traffic Control Services admitted staff detected around one unexplained flying object every month.

Dr David Clarke, a Sheffield Hallam academic and the UFO consultant for the National Archives, said: “The aviation authorities obviously think this is something they should continue to look into and if you are a regular air traveller, you are likely to agree.”

Dr Clarke, a sceptic on UFO issues, said: “This latest sighting is interesting, because it is detailed and clear. These pilots don’t file these reports for something and nothing. There was obviously something there.”

Chris Yates, an aviation consultant, said: “Although we assume when these things happen, a UFO is responsible, there is usually an explanation that materialises at some point.”

http://www.telegraph.co.uk/news/newstopics/howaboutthat/ufo/10551201/Jet-in-near-miss-with-UFO.html

Durham man with ALS achieves Krispy Kreme dream

Vhris

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In a speech a few weeks ago at Durham Academy, his high-school alma mater, Chris Rosati told students about a sweet dream of his.

He wanted to hijack a Krispy Kreme doughnut delivery truck and, with the cops chasing him, drive around tossing out free confections and cheer. Robin Hood, with baked goods.

The normally jaded teens embraced the idea with such enthusiasm that Rosati – already inclined to mischief – became determined to make it happen.

But every successful dreamer is also a realist, and Rosati knew his chances of getting away with a loaded doughnut truck were pretty slim, especially since he was diagnosed three years ago with amyotrophic lateral sclerosis. He can still walk, with assistance, but the degenerative neuromuscular disorder, which is ultimately fatal, has slowed him down.

He would need some help.

Rosati, a self-employed marketing consultant, knew what to do. He set up a Facebook page called A Krispy Kreme Heist, where he described his plan. He solicited “likes,” in the hopes that eventually, Winston-Salem-based Krispy Kreme would hear about it, lend him a truck and driver, and give him some doughnuts to give away.

Since he got sick, he explained, “I’m more open than ever to chasing my dreams … even odd ones like this.”

His story traveled like the scent of Original Glazed hot off the line. Within eight hours, Krispy Kreme corporate officials heard about Rosati’s idea.

“We got in touch with Chris and told him, ‘Don’t steal one of our trucks,’” said Megan Brock, directer of marketing. “We’ll give you the Krispy Kreme Cruiser and a thousand doughnuts.”

The Cruiser is a 1960 Flexible Starliner bus restored and christened last year for the company’s 75th anniversary. Krispy Kreme likes to say it’s one sweet ride that travels the country for promotional events.

Tuesday, its route was chosen by Rosati, who had the driver go to Duke University Medical Center, where he visited a cancer treatment center, a bone marrow transplant facility and the clinic where he gets treatment for his ALS.

After that, it was on to Durham Academy, where 400 high-schoolers had been assembled on the sidewalk without knowing why.

They figured it out when the Cruiser rolled into the parking lot, with its trademark green polka dots and Krispy Kreme bow-tie logo. They screamed and hooted.

“I told y’all to live out your dreams, as dumb as they may be sometimes,” he told the students as he got off the bus.

They would each get a doughnut, he promised, but then he asked a favor. Would some of them take a box, go out into the community and give them away just to see people smile?

“You get 12 chances in that box to make somebody happy,” he said.

Rosati’s wife, Anna, said the couple would use video of the day’s events to inspire others toward random acts of kindness through Rosati’s nonprofit, called Inspire MEdia. Eventually, Anna Rosati said, the couple hope the foundation will be able to help people fund their own uplifting projects.

http://www.journalnow.com/news/state_region/article_8a8f4da8-5fb0-11e3-ad14-001a4bcf6878.html

Thanks to Dr. Goldman for bringing this to the It’s Interesting community.

Man Flu

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New study suggests that men may actually suffer more when they have influenza because high levels of testosterone can weaken immune response.

For years women have cried “man flu” when men make a fuss over a few sniffles.

But a new study suggests that men may actually suffer more when they are struck down with flu – because high levels of testosterone can weaken their immune response.

The study by Stanford University School of Medicine, examined the reactions of men and women to vaccination against flu.

It found women generally had a stronger antibody response to the jab than men, giving them better protection against the virus.

Men with lower testosterone levels also had a better immune response, more or less equivalent to that of women.

It has long been suggested that men might be more susceptible to bacterial, viral, fungal and parasitic infection than women are.

The study published in the Proceedings of the National Academy of Sciences, found women had higher blood levels of signaling proteins that immune cells pass back and forth, when the body is under threat.

Previous research has found that testosterone has anti-inflammatory properties, suggesting a possible interaction between the male sex hormone and immune response.

Professor of microbiology and immunology Mark Davis said: “This is the first study to show an explicit correlation between testosterone levels, gene expression and immune responsiveness in humans.

“It could be food for thought to all the testosterone-supplement takers out there.”

Scientists said they were left perplexed as why evolution would designed a hormone that enhances classic male sexual characteristics – such as muscle strength, beard growth and risk-taking propensity – yet left them with a weaker immune system.

Previous studies have found that while women may accuse men of exaggerating when they have flu, females who are more likely to admit to having sniffles and sneezes.

The research, carried out by London School of Hygiene and Tropical Medicine last winter, shows that women are are 16 per cent more likely to say they are ill.

http://www.telegraph.co.uk/health/healthnews/10536083/Man-flu-the-truth-that-women-dont-want-to-hear.html

‘Jumping Genes’ Linked to Schizophrenia

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Roaming bits of DNA that can relocate and proliferate throughout the genome, called “jumping genes,” may contribute to schizophrenia, a new study suggests. These rogue genetic elements pepper the brain tissue of deceased people with the disorder and multiply in response to stressful events, such as infection during pregnancy, which increase the risk of the disease. The study could help explain how genes and environment work together to produce the complex disorder and may even point to ways of lowering the risk of the disease, researchers say.

Schizophrenia causes hallucinations, delusions, and a host of other cognitive problems, and afflicts roughly 1% of all people. It runs in families—a person whose twin sibling has the disorder, for example, has a roughly 50-50 chance of developing it. Scientists have struggled to define which genes are most important to developing the disease, however; each individual gene associated with the disorder confers only modest risk. Environmental factors such as viral infections before birth have also been shown to increase risk of developing schizophrenia, but how and whether these exposures work together with genes to skew brain development and produce the disease is still unclear, says Tadafumi Kato, a neuroscientist at the RIKEN Brain Science Institute in Wako City, Japan and co-author of the new study.

Over the past several years, a new mechanism for genetic mutation has attracted considerable interest from researchers studying neurological disorders, Kato says. Informally called jumping genes, these bits of DNA can replicate and insert themselves into other regions of the genome, where they either lie silent, doing nothing; start churning out their own genetic products; or alter the activity of their neighboring genes. If that sounds potentially dangerous, it is: Such genes are often the culprits behind tumor-causing mutations and have been implicated in several neurological diseases. However, jumping genes also make up nearly half the current human genome, suggesting that humans owe much of our identity to their audacious leaps.

Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation. Although Gage and colleagues have found that increased L1 is associated with mental disorders such as Rett syndrome, a form of autism, and a neurological motor disease called Louis-Bar syndrome, “no one had looked very carefully” to see if the gene might also contribute to schizophrenia, he says.

To investigate that question, principal investigator Kazuya Iwamoto, a neuroscientist; Kato; and their team at RIKEN extracted brain tissue of deceased people who had been diagnosed with schizophrenia as well as several other mental disorders, extracted DNA from their neurons, and compared it with that of healthy people. Compared with controls, there was a 1.1-fold increase in L1 in the tissue of people with schizophrenia, as well as slightly less elevated levels in people with other mental disorders such as major depression, the team reports today in Neuron.

Next, the scientists tested whether environmental factors associated with schizophrenia could trigger a comparable increase in L1. They injected pregnant mice with a chemical that simulates viral infection and found that their offspring did, indeed, show higher levels of the gene in their brain tissue. An additional study in infant macaques, which mimicked exposure to a hormone also associated with increased schizophrenia risk, produced similar results. Finally, the group examined human neural stem cells extracted from people with schizophrenia and found that these, too, showed higher levels of L1.

The fact that it is possible to increase the number of copies of L1 in the mouse and macaque brains using established environmental triggers for schizophrenia shows that such genetic mutations in the brain may be preventable if such exposures can be avoided, Kato says. He says he hopes that the “new view” that environmental factors can trigger or deter genetic changes involved in the disease will help remove some of the disorder’s stigma.

Combined with previous studies on other disorders, the new study suggests that L1 genes are indeed more active in the brain of patients with neuropsychiatric diseases, Gage says. He cautions, however, that no one yet knows whether they are actually causing the disease. “Now that we have multiple confirmations of this occurring in humans with different diseases, the next step is to determine if possible what role, if any, they play.”

One tantalizing possibility is that as these restless bits of DNA drift throughout the genomes of human brain cells, they help create the vibrant cognitive diversity that helps humans as a species respond to changing environmental conditions, and produces extraordinary “outliers,” including innovators and geniuses such as Picasso, says UC San Diego neuroscientist Alysson Muotri. The price of such rich diversity may be that mutations contributing to mental disorders such as schizophrenia sometimes emerge. Figuring out what these jumping genes truly do in the human brain is the “next frontier” for understanding complex mental disorders, he says. “This is only the tip of the iceberg.”

Thanks to Dr. Rajadhyaksha for bringing this to the attention of the It’s Interesting community.

http://news.sciencemag.org/biology/2014/01/jumping-genes-linked-schizophrenia

When Whale Watching Turns Deadly

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Humpback whales are facing new dangers in Hawaiian waters, where more than 10,000 of the cetaceans congregate from December to April to calve and breed. That’s the conclusion of an analysis of historical records of ship strikes on humpback whales (Megaptera novaeangliae) in the seas around the Hawaiian Islands between 1975 and 2011. In that 36-year period, 68 such strikes were reported, including the one that injured the humpback calf in the photo above. The scientists have not yet been able to quantify the number of whales lethally wounded or killed outright by such hits. Because more than 63% of the collisions involved calves and subadults, the scientists conclude that these younger animals are particularly susceptible to being struck, most likely because they spend more time at the surface to breathe than do adults. Worryingly, the number of strikes has steadily increased over the years, the team reports in the Journal of Cetacean Research and Management—and not because there are more whales. Instead, the increase is apparently due to tourism. The majority of vessels that have collided with whales in Hawaii are small- to medium-sized boats, less than 21.2 meters in length, the scientists say, which happens to be the size of commercial whale-watching vessels. Federal regulations require these boats to remain at least 100 yards distance from the humpbacks. They may be keeping their distance while observing the whales, but not when under way: The majority of collisions occurred when the vessels were travelling at 10 to 19 knots, the team reports—apparently, too fast to avoid colliding with the very animals the skippers and tourists have come out to watch.

http://news.sciencemag.org/plants-animals/2013/12/scienceshot-when-whale-watching-turns-deadly

Stretch Or Splat? How A Black Hole Kills You Matters … A Lot

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“Our hypothesis is that the inside of a black hole — it may not be there. Probably that’s the end of space itself. There’s no inside at all.”
– Joe Polchinski, physicist

It could rightly be called the most massive debate of the year: Physicists are locked in an argument over what happens if you fall into a black hole.

On one side are those who support the traditional view from Albert Einstein. On the other, backers of a radical new theory that preserves the very core of modern physics by destroying space itself.

Regardless of who’s right, the new take on black holes could lead to a better understanding of the universe, says Leonard Susskind, a physicist at Stanford University. “This is the kind of thing where progress comes from.”

Black holes are regions of space so dense that nothing, not even light, can escape.

There’s a long-standing view about what would happen if you fell into one of these holes. At first, you’re not going to notice much of anything — but the black hole’s gravity is getting stronger and stronger. And eventually you pass a point of no return.

“It’s kind of like you’re rowing on Niagara Falls, and you pass the point [where] you can’t row fast enough to escape the current,” Susskind says. “Well, you’re doomed at that point. But passing the point of no return — you wouldn’t even notice it.”

Now you can’t get out. And gravity from the black hole is starting to pull on your feet more than your head. “The gravity wants to sort of stretch you in one direction and squeeze you in another,” says Joe Polchinski, a physicist at the University of California, Santa Barbara. He says the technical term for this stretching is spaghettification.

“It’d be kind of medieval,” says Polchinkski. “It’d be like something on Game of Thrones.”

In Einstein’s version of events, that’s the end. But Polchinski has a new version of things: “Our hypothesis is that the inside of a black hole — it may not be there,” he says.

So what’s inside the black hole? Nothing, Polchinski says. Actually even less than that. “Probably that’s the end of space itself; there’s no inside at all.”
This “no inside” idea may sound outrageous, but it’s actually a stab at solving an even bigger problem with black holes.

According to the dominant theory of physics — quantum mechanics — information can never disappear from the universe. Put another way, the atoms in your body are configured in a particular way. They can be rearranged (radically if you happen to slip inside a black hole). But it should always be possible, at least in theory, to look at all those rearranged atoms and work out that they were once part of a human of your dimensions and personality.

This rule is absolutely fundamental. “Everything is built on it,” says Susskind. “If it were violated, everything falls apart.”

For a long time, black holes stretched this rule, but they didn’t break it. People thought that if you fell into a black hole, your spaghettified remains would always be in there, trapped beyond the point of no return.

That is, until the famous physicist Stephen Hawking came along. In the 1970s, Hawking showed that, according to quantum mechanics, a black hole evaporates — very slowly, it vanishes. And that breaks the fundamental rule because all that information that was once in your spaghettified remains vanishes with it.

This didn’t seem to bother Hawking. (“I’m not a psychiatrist, and I can’t psychoanalyze him,” Susskind says.) But it has bothered a lot of other physicists since.

And in the intervening years, work by another theorist — Juan Maldacena, with Princeton’s Institute for Advanced Study — seems to show that Hawking was wrong. Information has to get out of the black hole … somehow. But nobody knows how.

So Polchinski took another look. “We took Hawking’s original argument,” he says, “and very carefully ran it backwards.”

And Polchinski and his colleagues found one way to keep things from vanishing when they fall inside a black hole — they got rid of the inside. By tearing apart the fabric of space beyond the point of no return, the group was able to preserve the information rule of quantum mechanics.

In this version, anything falling into a black hole is instantly vaporized at the point of no return, in a fiery storm of quantum particles. Particles coming from the hole collectively carry away any and all information about the object that’s falling in.

So in Polchinski’s version, when you fall into a black hole, you don’t disappear. Instead, you smack into the end of the universe.

“You just come to the end of space, and there’s nothing beyond it. Terminated,” Susskind says. All the information once contained in your atoms is re-radiated in a quantum mechanical fire.

This new version seems too radical to Susskind. “I don’t think this is true,” he says. “In fact, I think almost nobody thinks this is true — that space falls apart inside a black hole.”

Even Polchinski still feels that black holes should have insides. “My gut believes that the black hole has an interior,” he says. But, he adds, nobody’s been able to disprove his hypothesis that it doesn’t.

“Every counterargument I’ve seen is flawed,” Polchinski says.

Susskind agrees: “Nobody quite knows exactly what’s wrong with their argument — and that’s what makes this so important and interesting.”

And as crazy as it sounds, this is progress. In the year ahead, Susskind hopes someone can find the flaw in Polchinski’s argument, just the way Polchinski found a flaw in Stephen Hawking’s argument. But it will be awhile before we understand black holes inside and out.

http://www.npr.org/2013/12/27/256897343/stretch-or-splat-how-a-black-hole-kills-you-matters-a-lot