Biogen Reports Its Alzheimer’s Drug Sharply Slowed Cognitive Decline

An experimental drug for Alzheimer’s disease sharply slowed the decline in mental function in a small clinical trial, researchers reported Friday, reviving hopes for an approach to therapy that until now has experienced repeated failures.

The drug, being developed by Biogen Idec, could achieve sales of billions of dollars a year if the results from the small trial are replicated in larger trials that Biogen said it hoped to begin this year. Experts say that there are no really good drugs now to treat Alzheimer’s.

Biogen’s stock has risen about 50 percent since early December, when the company first announced that the drug had slowed cognitive decline in the trial, without saying by how much. Analysts and investors had been eagerly awaiting the detailed results, some of them flying to France to hear Biogen researchers present them at a neurology meeting on Friday.

The drug, called aducanumab, met and in some cases greatly exceeded Wall Street expectations in terms of how much the highest dose slowed cognitive decline. However, there was a high incidence of a particular side effect that might make it difficult to use the highest dose.

Still, the net impression was positive. “Out-of-the-ballpark efficacy, acceptable safety,” Ravi Mehrotra, an analyst at Credit Suisse, wrote on Friday. Shares of Biogen rose $42.33, or 10 percent, to $475.98.

Alzheimer’s specialists were impressed, but they cautioned that it was difficult to read much from a small early-stage, or Phase 1, trial that was designed to look at safety, not the effect on cognition. Also, other Alzheimer’s drugs that had looked promising in early studies ended up not working in larger trials.

“It’s certainly encouraging,” said Dr. Samuel Gandy, director of the Center for Cognitive Health at Mount Sinai Hospital in New York, who was not involved in the study. He said the effect of the highest dose was “pretty impressive.”

Aducanumab, which until now has been called BIIB037, is designed to get rid of amyloid plaque in the brain, which is widely believed to be a cause of the dementia in Alzheimer’s disease. However, other drugs designed to prevent or eliminate plaque have failed in large clinical trials, raising questions about what role the plaque really plays.

Johnson & Johnson and Pfizer abandoned a drug they were jointly developing after it showed virtually no effect in large trials. Eli Lilly and Roche are continuing to test their respective drugs despite initial failures. Experts say there is some suggestion the drugs might work if used early enough, when the disease is still mild.

Biogen tried to increase its chances of success by treating patients with either mild disease or so-called prodromal disease, an even earlier stage. It also enrolled only patients shown to have plaque in their brains using a new imaging technique. In some trials of other drugs, some of the patients turned out not to have plaque, which could have been a reason the trials were not successful.

The results reported Friday were for 166 patients, who were randomly assigned to get one of several doses of the drug or a placebo. The drug not only slowed cognitive decline but also substantially reduced plaque in the brain, and higher doses were better than lower doses. Those are signs that the effects seen were from the drug.

“It would be kind of hard to get those kind of results by chance,” said Dr. Rachelle S. Doody, director of the Alzheimer’s Disease and Memory Disorders Center at Baylor College of Medicine, who was not involved in the study but has been a consultant to Biogen and many other companies.

On one measure of cognition, a 30-point scale called the mini-mental state exam or M.M.S.E., those receiving the placebo worsened by an average of 3.14 points over the course of a year. The decline at one year was only 0.58 points for those getting the highest dose and 0.75 points for a middle dose. The difference with a placebo was statistically significant for both doses.

On another measure of both cognition and the ability to function in daily tasks, patients in the placebo group worsened by an average of 2.04 points at one year. Those getting the highest dose of the drug had a decline of only 0.59, a statistically significant difference.

Some analysts said they would have been impressed if the drug had slowed the rate of cognitive decline by 20 or 30 percent. But the actual reduction for the high dose was above 70 percent. They said the drug’s effect was stronger than that of Lilly’s drug.

A major side effect was a localized swelling in the brain, known as A.R.I.A.-E. This has been seen with other drugs in this class, though the rate for aducanumab seems higher.

Among patients with a genetic variant that raises the risk of getting Alzheimer’s, 55 percent of those who got the highest dose suffered this side effect, and about 35 percent of the high-dose patients dropped out of the trial because of this. Among those without the genetic variant, 17 percent of those who got the highest dose suffered the side effect and 8 percent discontinued treatment.

Biogen said the swelling often did not cause symptoms and probably could be managed by watching for it and reducing doses. Dr. Doody and Dr. Gandy agreed.

But Dr. Thomas M. Wisniewski, a professor of neurology at NYU Langone Medical Center, disagreed. “Most clinicians would find that unacceptable,” he said in a conference call hosted by the Wall Street firm Evercore ISI. He said the side effect was “something you definitely don’t want happening in your patients.”

Over all, however, Dr. Wisniewski was enthusiastic, saying the drug looked to be “way better” than Lilly’s.

A lesser dose might suffice. There were no discontinuations from this side effect among patients taking a middle dose. And that middle dose also seemed somewhat effective in slowing cognitive decline.

The results were presented in Nice, France, at the International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders.

Vodafone warns mobile phone users in London to expect up to two months of slower networks because nesting peregrine falcons on masts cannot be moved

Mobile phone users have been warned they could face reception problems because it is the peregrine falcon nesting season.

Vodafone said three pairs of the world’s fastest bird have been found beside masts across London, including a church, hospital and office building, and could be slowing down networks.

Phone masts are a popular nesting site for the bird of prey and the company will be unable to remove the nests until the chicks are hatched and leave, which could take two months.

It is a criminal offence under the Wildlife and Countryside Act of 1981 to disturb the birds while they are nesting.

Vodafone spokesman Simon Gordon said: “We apologise to any customers who experience a dip in service, but we have to respect the environment and the law.

“This is the first time to my knowledge we have had this in London, so for us it is unprecedented. They can sometimes nest on the mast itself – which is like a big metal climbing frame – or use the box underneath, where the computer stuff sits.”

Mr Gordon, who is himself a wildlife enthusiast and bird watcher, added: “At the moment, we are a year into a £200million upgrade works and we are going to individual sites to upgrade the equipment.

“If there is a peregrine falcon nesting there, we have to abide by the law and not approach the nest and call the experts to go onto the site to assess where they are nesting.”

n April 2013, Vodafone customers complained about poor reception in Southampton. Engineers called out to repair a faulty transmitter found a peregrine falcon nesting next to it.

The company had to tell its frustrated customers they were unable to repair the faulty mast until the chicks had left the nest.

Peregrine falcons, which can travel at speeds of up to 240mph, have seen a revival in recent years.

The birds nearly became extinct in the 1960s after their existence was threatened by pesticides, but laws controlling use of pesticides meant their numbers slowly recovered.

The Royal Society for the Protection of Birds has estimated there are 1,402 breeding pairs in the UK and there are currently thought to be 30 nesting pairs in the capital.

http://www.telegraph.co.uk/news/newstopics/howaboutthat/11482677/Peregrine-falcons-nesting-on-Vodafone-mobile-phone-masts-cause-poor-signal.html

Water is a new cash-crop in California

The rice industry in the Sacramento Valley is taking a hard hit with the drought. Some farmers are skipping out on their fields this year, because they are cashing in on their water rights.

Many fields will stay dry because farmers will be doing what was once considered unthinkable: selling their water to Southern California.

“In the long term, if we don’t make it available we’re afraid they’ll just take it,” said Charlie Mathews, a fourth generation rice farmer with senior rights to Yuba River water.

He and his fellow growers have agreed to sell 20 percent of their allotment to Los Angeles’s Metropolitan Water District as it desperately searches to add to its dwindling supply.

It’s not really surprising that Southern California is looking for a place to buy water. But what is making news is how much they’ve agreed to pay for it: $700 per acre foot of water.

Just last year, rice farmers were amazed when they were offered $500 per acre foot. This new price means growers will earn a lot more money on the fields they don’t plant, making water itself the real cash crop in California.

“It’s much more than we ever expected to get. But at the same time, that just shows the desperation of the people that need it,” Mathews said.

The ripple effect of this will be felt around the entire state. If a Bay Area water district needs to buy more water, it will now be competing with Los Angeles to do it.

“They have to pay whatever the last price, the highest price, people will pay,” Mathews said.

http://sanfrancisco.cbslocal.com/2015/03/17/drought-some-northern-california-farmers-not-planting-sell-water-rights-los-angeles/

Thanks to Kebmodee for bringing this to the attention of the It’s Interesting community.

Catholic Church in San Francisco installs water spray wystem to drive away homeless people seeking shelter

Saint Mary’s Cathedral, the principal church of the Archdiocese of San Francisco, has installed a watering system to keep the homeless from sleeping in the cathedral’s doorways.

The cathedral is the home church of the Archbishop. There are four tall side doors, with sheltered alcoves, that attract homeless people at night.

“They actually have signs in there that say, ‘No Trespassing,’” said a homeless man named Robert.

But there are no signs warning the homeless about what happens in these doorways, at various times, all through the night. Water pours from a hole in the ceiling, about 30 feet above, drenching the alcove and anyone in it.

The shower runs for about 75 seconds, every 30 to 60 minutes starting before sunset, simultaneously in all four doorways, and soaks homeless people, and their belongings.

The water doesn’t clean the area. There are syringes, cigarette butts, soggy clothing and cardboard. There is no drainage system. The water pools on the steps and sidewalks.

A neighbor who witnessed the drenching said, “I was just shocked, one because it’s inhumane to treat people that way. The second thing is that we are in this terrible drought.

Jennifer Friedenbach, executive director of the Coalition on Homeless said, “It’s very shocking, and very inhumane. There’s not really another way to describe it. Certainly not formed on the basis of Catholic teachings.”

A cathedral staff member confirmed the system was installed, perhaps a year ago, to deter the homeless from sleeping there.

https://cbssanfran.wordpress.com/2015/03/18/homeless-saint-marys-cathedral-archdiocese-san-francisco-intentionally-drenched-water-sleeping/?preview=true&preview_id=471419&preview_nonce=a7ea4dcc06

Baltimore Ravens Offensive Lineman John Urschel Publishes Paper In Math Journal

Some NFL players spend their offseason working out. Others travel around the world. Baltimore Ravens offensive lineman John Urschel has done both while also getting an article published in a math journal.

Urschel, the Ravens’ 2014 fifth-round pick who graduated from Penn State with 4.0 GPA, also happens to be a brilliant mathematician. This week he and several co-authors published a piece titled “A Cascadic Multigrid Algorithm for Computing the Fiedler Vector of Graph Laplacians” in the Journal of Computational Mathematics. You can read the full piece here: http://arxiv.org/abs/1412.0565

Here’s the summary of the paper:

“In this paper, we develop a cascadic multigrid algorithm for fast computation of the Fiedler vector of a graph Laplacian, namely, the eigenvector corresponding to the second smallest eigenvalue. This vector has been found to have applications in fields such as graph partitioning and graph drawing. The algorithm is a purely algebraic approach based on a heavy edge coarsening scheme and pointwise smoothing for refinement. To gain theoretical insight, we also consider the related cascadic multigrid method in the geometric setting for elliptic eigenvalue problems and show its uniform convergence under certain assumptions. Numerical tests are presented for computing the Fiedler vector of several practical graphs, and numerical results show the efficiency and optimality of our proposed cascadic multigrid algorithm.”

When he’s not protecting Joe Flacco, the 23-year-old Urschel enjoys digging into extremely complicated mathematical models.

“I am a mathematical researcher in my spare time, continuing to do research in the areas of numerical linear algebra, multigrid methods, spectral graph theory and machine learning. I’m also an avid chess player, and I have aspirations of eventually being a titled player one day.”

– See more at: http://yahoo.thepostgame.com/blog/balancing-act/201503/john-urschel-baltimore-ravens-nfl-football-math#sthash.avUHj2Tm.dpuf

Thanks to Kebmodee for bringing this to the attention of the It’s Interesting community.

Spain finds Don Quixote writer Cervantes’ tomb in Madrid


Who was Cervantes? BBC News has the essential facts
1547: Born near Madrid
1571: Shot and wounded at Battle of Lepanto
1575: Captured and enslaved for five years in Algiers
1605: Publishes first part of The Ingenious Gentleman Don Quixote of La Mancha, second part in 1615. Don Quixote is man obsessed with chivalry who sets out in search of adventure on his ageing horse Rocinante and with his faithful squire Sancho Panza
1616: Cervantes dies aged 68, with six teeth remaining. Buried at Convent of Barefoot Trinitarians
Grave lost when convent rebuilt

Forensic scientists say they have found the tomb of Spain’s much-loved giant of literature, Miguel de Cervantes, nearly 400 years after his death.

They believe they have found the bones of Cervantes, his wife and others recorded as buried with him in Madrid’s Convent of the Barefoot Trinitarians.

Separating and identifying his badly damaged bones from the other fragments will be difficult, researchers say.

The Don Quixote author was buried in 1616 but his coffin was later lost.

When the convent was rebuilt late in the 17th Century, his remains were moved into the new building and it has taken centuries to rediscover the tomb of the man known as Spain’s “Prince of Letters”.

“His end was that of a poor man. A war veteran with his battle wounds,” said Pedro Corral, head of art, sport and tourism at Madrid city council.

The team of 30 researchers used infrared cameras, 3D scanners and ground-penetrating radar to pinpoint the burial site, in a forgotten crypt beneath the building.

Inside one of 33 niches found against the far wall, archaeologists discovered a number of adult bones matching a group of people with whom Cervantes had been buried, before their tombs were disturbed and moved into the crypt.

“The remains are in a bad state of conservation and do not allow us to do an individual identification of Miguel de Cervantes,” said forensic scientist Almudena Garcia Rubio.

“But we are sure what the historical sources say is the burial of Miguel de Cervantes and the other people buried with him is what we have found.”

Further analysis may allow the team to separate the bones of Cervantes from those of the others if they can use DNA analysis to work out which bones do not belong to the author.

Investigator Luis Avial told a news conference on Tuesday that Cervantes would be reburied “with full honours” in the same convent after a new tomb had been built, according to his wishes.

“Cervantes asked to be buried there and there he should stay,” said Luis Avial, georadar expert on the search team.

The convent’s religious order helped pay for his ransom after he was captured by pirates and held prisoner for five years in Algiers.

The crypt will be opened to the public next year for the first time in centuries to coincide with the 400th anniversary of Cervantes’ death.

Mr Corral told the BBC that the project had not just been about finding the bones of the author but of honouring his memory and encouraging people to learn more about him.

Many people may be rediscovering Cervantes because of the search, he said.

Born near Madrid in 1547, Cervantes has been dubbed the father of the modern novel for The Ingenious Gentleman Don Quixote of La Mancha, published in two parts in 1605 and 1615.

The book is thought to be one of the most widely read and translated books in the world.

http://www.bbc.com/news/world-europe-31852032

World’s oldest psychiatric hospital opens new museum

The world’s oldest psychiatric institution, the Bethlem Royal Hospital outside London, this week opened a new museum and art gallery charting the evolution in the treatment of mental disorders.

The original hospital was founded in 1247 in what is now central London and the name spawned the English word “bedlam” meaning chaos and madness.

In the 18th century visitors could pay to gawk at the hospital’s patients and, three centuries later, stereotypes about mental illness still abound.

“The museum is to do with challenging the stigma around mental health and one of the main ways you can do that is actually get people to walk onto the site and realise that this is not a frightening, threatening and dark place,” Victoria Northwood, head of the Archives and Museum, told AFP.

The bleak period in the history of mental treatment is addressed but not dwelled upon in the museum.

Iron and leather shackles used until the mid-19th century to restrain patients are displayed behind a wall of mirrors so they cannot be seen directly.

A padded cell is deconstructed and supplemented with audio of a patient describing what is was like to be locked inside.

The exhibition is full of interactive exhibits, including a video where the visitor is challenged to decide whether to commit a young woman, in denial about the dangers of her anorexia, to hospital against her will.

The decision is surprisingly difficult and it shows the complexity in diagnosing ailments linked to the brain, which we still know comparatively little.

“We are just getting across that this is not a black and white issue. It is not very easy. Human beings aren’t very easy,” Northwood said.

Art features strongly throughout the space, starting with the imposing 17th century statues “Raving Madness” and “Melancholy Madness” by Caius Gabriel Cibber, which used to stand at the entrance to the Bethlem hospital when it was in central London.

Also included are paintings by current or former patients, like Dan Duggan’s haunting charcoal “Cipher” series of a man’s elongated face—a testament to the 41-year-old’s inner turmoil.

Duggan, who made several suicide attempts and was detained three times under the mental health act including at Bethlem, said art was an instrumental tool in his recovery.

“A lot of the time you spend in hospital, particularly a psychiatric hospital, is very prescribed.

“When you’re engaged in a creative process, you’re able to be free of all of that for a while and the power is back in your hands to do whatever you want to do,” he said.

Visual artist and dancer Liz Atkin grew up in an alcoholic household. She developed dermatillomania or Compulsive Skin Picking from the age of eight as a way to manage the stress.

“I could have ended things in a very different way,” said Atkin, now aged 38.

Atkin received treatment and works with patients at the anxiety unit of Bethlem, which is now located in spacious grounds about one hour south of London.

She said the new museum and gallery is a unique space to encourage healing.

“Making artwork isn’t a complete cure and I personally don’t think that I’m cured, but I think it provides a very powerful outlet for some of those things that are hard to talk about.”

http://medicalxpress.com/news/2015-02-world-oldest-psychiatric-hospital-museum.html

Ditch the Uptalk — How to Make Your Voice Powerful

In an ideal world, career success would be based on meaningful factors like talent, original thinking, and performance. But in actuality, seemingly trivial influences exert a greater impact on how far ahead we get than we may think.

Proof: Recent research pinpointed a strong correlation between power and voice tone, finding that people in high-ranking positions speak differently than those with a lower status, and that others can accurately detect how prominent someone is just by the sound of his or her voice.

Want to harness this to raise your own power profile? Read on for solutions to score a smooth, commanding voice that screams success.

Do You Know What You Really Sound Like?

“You wouldn’t dream of walking into a boardroom meeting or job interview in raggedy jeans and flip-flops,” says Darlene Price, president of the executive coaching firm Well Said, Inc. “And your voice is an equally important reflection of your professional presence.”

Price experienced the impact of speech on success firsthand: Originally from a rural farming community in the mountains of North Carolina, she later attended Appalachian State University, graduated at the top of her class, and landed a job in sales.

But despite her hard work, she struggled to get clients. “People wouldn’t give me the time of day — I couldn’t even get an appointment,” she remembers. She was clueless about why doors were being slammed in her face, until her boss shared an insight that changed the course of her life.

He took her aside and told her, “You are highly capable and we are in support of your potential, but your voice is holding you back.” Price was blown away — like most of us, she was completely unaware of what she sounded like and how she came across to others as a result. But her supervisor’s revelation sunk in.

“Not only did I have a heavy Southern accent that was difficult to understand, but I also used a squeaky, breathy baby voice, and I had a speech impediment — I couldn’t pronounce r’s or s’s. On top of that, I was shy, and lacked the confidence to speak up,” she says. “I knew that I had to work on my voice to ensure my future. It was clear to me that I would not have the career I wanted otherwise.”

As Price realized, the sneaky thing about voice is that what you hear in your head could be completely different from how you sound to others. So the first step to figuring out whether your chatter might be hindering your career is to open your ears.

Use the Voice Memo function on your iPhone (or download the free recording app Cogi for Android) to tape yourself during a conversation. Then pop in a set of headphones, hit play … and don’t be surprised if your jaw hits the floor.

Drop the Uptalk

If your voice rises at the end of every sentence? Like Shoshanna on Girls? So that it sounds like you’re asking a question? Even when you’re not? Then you’ve fallen into the habit of uptalk, and it’s threatening your workplace credibility. “Not only is it annoying and distracting, but it gives the impression that you’re unsure of yourself and constantly seeking approval,” says Price, who notes this speech pattern is on the rise among her clientele.

Luckily, she has a fix. Hold one arm straight out in front of you, and begin reading aloud from a book or magazine. Whenever you reach a period, lower your arm down to your side, and drop your pitch at the same time. “It’s a technique called kinesthetic anchoring, when you associate a physical action with a certain vocal pattern,” explains Price. “The voice naturally follows the body, so lowering your arm triggers your brain to lower your voice.”

Practice this for 30 minutes a day; after three months you should be seeing progress, and after a year downward inflection will be like second nature.

Ditch the Baby Talk

No matter how accomplished you are, you probably won’t be taken seriously if you sound like a third-grader. Price once worked with a CEO who found herself losing out on opportunities as a direct result of her squeaky tone. “She had two PhDs after her name, an incredible history of success, and Wall Street loved her on paper,” she says. “But all that brilliance was masked because people could not get past her voice.” Unwarranted as it may be, people came away with the impression that she was immature and low on the totem poll.

The solution? Yawns are actually a powerful tool to help your little girl voice grow up. “A high-pitched tone is caused by constriction in the throat muscles,” explains Jane Fujita, voice and speech specialist, dialogue coach, and assistant professor at New York University’s Tisch School of the Arts. “Yawning stretches your pharynx, opening up space in the back of your mouth and allowing more air to pass through, which results in a lower, deeper pitch.” She suggests aiming for 20 yawns a day.

Also, start belting it out when you’re in the shower, listening to the car radio, or getting ready in the morning. “It’s uncomfortable to sing with a tightened pharynx, so you’ll naturally begin to release those tense muscles and lengthen your breath,” says Fujita. “Often, this will carry over to the rest of your life.”

Channel Diane Sawyer, Not Kim Kardashian

You know that husky tone running rampant on reality television shows like Real Housewives and The Bachelor, and spouted by pop stars like Kesha and Katy Perry? Called vocal fry, it’s a speech pattern that female millennials are picking up in droves. “Originally thought to be a speech disorder, over the past few years, speech pathologists started noticing that young women were choosing to speak this way in order to mimic famous entertainers and fit into a peer group,” says Price.

But, much like Valley Girl talk of the ’80s and ’90s, vocal fry sabotages your professional stature. A study published in the journal PLOS ONE found that young women with a raspy register were perceived as less competent, educated, trustworthy, and hireable than those with a normal voice. (It hurts your throat as well as your career — the creaky tones are a result of your vocal chords rubbing against each other, which creates irritation.)

The good news: “Simply becoming aware of how you sound may be enough to motivate you to stop,” says Price.

This breath exercise can also help: Lie on your back, knees bent, and feet flat on the floor. Place a heavy book on your stomach, breathe deeply, and watch the book rise with each inhale and fall as you exhale. If the book isn’t moving much, that’s a sign your breath is shallow; focus on sending the breath lower, so that it originates in your diaphragm. As you exhale, breathe out a word, letter, or sounds like mmm or ahhh. “Good breath production is critical to good voice production,” says Price. “It gives your voice the air and power it needs to rise through your vocal chords.”

Take It Slooooow

Peoplewhotalkamileaminute are hurting themselves career-wise. “Rushing through gives the impression that you don’t value what you’re saying,” says Fujita. Plus, you might not get credit for your ideas, since people don’t have a chance to fully absorb them.

According to Price, the ideal speaking speed is 150 to 160 words per minute (this is the pace at which audio books are recorded, for example); motor mouths spout out a whopping 220 words per minute. A nifty trick to help you take your time is to talk or read out loud to yourself, and clap your hands at the end of every sentence. “This trains your brain to stop for punctuation marks,” notes Price.

But for many speed talkers, the root of the problem is that they aren’t using their breath optimally, jam-packing multiple sentences into a single exhale. So to kick-start a slower pace, you need to lengthen your breath. Begin by becoming aware of your breathing throughout the day. “Build an obsession with it,” urges Fujita. “How do you breathe when walking down the street, washing dishes, or talking to other people?” Once you start paying attention to the rhythm of your inhales and exhales, your breath will naturally extend.

And make sure you have good alignment, i.e., an erect posture and loose upper body. “To allow for the deep passage of breath, your diaphragm needs to drop and your belly must release,” says Fujita. “That can’t happen if you are holding tension in your torso or collapsing in the upper body.” Along the same lines, carve out time for relaxation, from yoga to meditation.

Quit Bingeing on Fillers

So, if you, like, can’t get out a simple, you know, sentence without, um, littering it with verbal detritus — then people are probably underestimating your talent. “Fillers make you sound as though you don’t know what you want to say, like you need to qualify all of your statements,” explains Fujita.

Instead, replace your likes and ums with a pause. “There is power in pausing,” says Fujita. “It allows you to hold the floor in between sentences and adds meaning to the next thing you say.” A beat of silence also gives the person you’re talking to time to digest your words.

But sometimes those pesky fillers continue to creep in. And while the occasional “you know” isn’t the end of the world, many people go overboard. One of Price’s clients, an exec for a Fortune 500 company, had a wake-up call after delivering a presentation to a major prospect. The decision maker for the group handed him a note reading, You said “um” 21 times in the first 60 seconds.

Give yourself a reality check by recording yourself during a conversation, then counting how many fillers you used. “As soon as you are made aware of this habit, your brain becomes engaged, which automatically helps you keep it under control,” says Price.

Or go a step further: Ask your partner or a friend to tap on the table whenever an um slips out, and then begin your sentence all over again. You can consider yourself cured once you reach two full minutes of filler-free speech. “This can be a frustrating exercise, but it has never failed my clients,” affirms Price. “They end up speaking in a more slow, thoughtful, deliberate fashion.”

Make Yourself Heard

What was that? I can’t hear you. Could you speak up? Come again? If you barely register above a whisper, what you say can come across as equally unsubstantial. “A breathy voice doesn’t give your words gravitational weight,” says Fujita. “When you have more vocal amplitude, you have more power.”

But putting oomph into your speech isn’t as simple as just talking louder. Not only will that feel unnatural, but you’ll sound like you’re shouting — not quite the impression you’re going for. Instead, try visualizing your voice as a ball you can bounce off the walls, suggests Fujita. “Think about landing your voice across the room,” she says. This will help you project without coming across as aggressive.

Also, since shyness can often be part of the problem for soft speakers, consider joining a local toastmaster’s club — an organization to help you become a more effective leader and communicator. You can practice public speaking, receive feedback on your performance, and become more comfortable sharing your opinions with a group.

Remember, putting time and effort into developing your voice is tremendously important. “A restricted voice that contains disempowering speech habits will jeopardize your opportunity to fully express your power in the world,” says Price. “You will augment your chances of receiving promotions, raises, and job offers through a strong speaking voice.”

https://www.dailyworth.com/posts/3308-how-to-change-your-voice

New study shows that use of psychedelic drugs does not increase risk of mental illness

An analysis of data provided by 135,000 randomly selected participants – including 19,000 people who had used drugs such as LSD and magic mushrooms – finds that use of psychedelics does not increase risk of developing mental health problems. The results are published in the Journal of Psychopharmacology.

Previously, the researchers behind the study – from the Norwegian University of Science and Technology in Trondheim – had conducted a population study investigating associations between mental health and psychedelic use. However, that study, which looked at data from 2001-04, was unable to find a link between use of these drugs and mental health problems.

“Over 30 million US adults have tried psychedelics and there just is not much evidence of health problems,” says author and clinical psychologist Pål-Ørjan Johansen.

“Drug experts consistently rank LSD and psilocybin mushrooms as much less harmful to the individual user and to society compared to alcohol and other controlled substances,” concurs co-author and neuroscientist Teri Krebs.

For their study, they analyzed a data set from the US National Health Survey (2008-2011) consisting of 135,095 randomly selected adults from the US, including 19,299 users of psychedelic drugs.

Krebs and Johansen report that they found no evidence for a link between use of psychedelic drugs and psychological distress, depression, anxiety or suicidal thoughts, plans and attempts.

In fact, on a number of factors, the study found a correlation between use of psychedelic drugs and decreased risk for mental health problems.

“Many people report deeply meaningful experiences and lasting beneficial effects from using psychedelics,” says Krebs.

However, Johansen acknowledges that – given the design of the study – the researchers cannot “exclude the possibility that use of psychedelics might have a negative effect on mental health for some individuals or groups, perhaps counterbalanced at a population level by a positive effect on mental health in others.”

Despite this, Johansen believes that the findings of the study are robust enough to draw the conclusion that prohibition of psychedelic drugs cannot be justified as a public health measure.

Krebs says:

“Concerns have been raised that the ban on use of psychedelics is a violation of the human rights to belief and spiritual practice, full development of the personality, and free-time and play.”

Commenting on the research in a piece for the journal Nature, Charles Grob, a paediatric psychiatrist at the University of California-Los Angeles, says the study “assures us that there were not widespread ‘acid casualties’ in the 1960s.” However, he urges caution when interpreting the results, as individual cases of adverse effects can and do occur as a consequence of psychedelic use.

For instance, Grob describes hallucinogen persisting perception disorder, sometimes referred to as “a never-ending trip.” Patients with this disorder experience “incessant distortions” in their vision, such as shimmering lights and colored dots. “I’ve seen a number of people with these symptoms following a psychedelic experience, and it can be a very serious condition,” says Grob.

http://www.medicalnewstoday.com/articles/290461.php

Ecstasy and other drugs temporarily legal in Ireland

Possession of ecstasy and other drugs is currently legal in Ireland, but only for a day, after a court ruling on Tuesday morning.

A written judgment released by the Republic’s court of appeal said part of the Misuse of Drugs Act 1977, which allows certain substances to be controlled, is unconstitutional, meaning all government orders banning substances such as ecstasy and magic mushrooms are void – and it is not an offence to possess them.

Specifically, the court found that the act was being added to via ministerial order and without consulting the Oireachtas (both houses of the Irish parliament) and deemed this unconstitutional.

The appeal court’s ruling came in favor of a man who was prosecuted for possession of methylethcathinone, which was among a number of substances put on the controlled drugs list in 2010.

Stanislav Bederev denied the charge of having the substance for supply in 2012, and then brought a high court challenge in Dublin seeking to stop his trial, claiming that additions to the 1977 act were unconstitutional.

Bederev’s legal team argued it was not lawful to put the substance on the controlled drug list because there are no principles and policies guiding the introduction of such rules – and specifically no consultation with the Irish parliament.

The Irish government now has to force through emergency legislation in its parliament on Tuesday evening in response to the ruling.

The emergency law won’t come into place until the Republic’s second chamber, the Seanad, endorses the legislation. Following that the country’s president, Michael D Higgins, will have to gave his approval.

http://www.theguardian.com/world/2015/mar/10/irish-es-are-smiling-ecstasy-drugs-temporarily-legal-in-ireland