Alzheimer’s Drug Discovery Foundation (ADDF) and Harrington Discovery Institute Partnership Helps Move Promising Alzheimer’s Research from Bench toward Bedside

Research by 2015 ADDF-Harrington Scholar Jerri Rook, Ph.D. of Vanderbilt University leads to licensing agreement to develop drugs that improve memory.

A recently announced licensing agreement between drug maker Acadia Pharmaceuticals and Vanderbilt University represents a major milestone for the ADDF-Harrington Scholar Award Program, which provided funding and pharmaceutical expertise to support the research in the early phases. Acadia and Vanderbilt will collaborate to develop and commercialize novel drug candidates targeting synaptic receptors in the brain, long thought to play a key role in Alzheimer’s disease.

“This type of licensing agreement is precisely the goal of the ADDF-Harrington partnership,” said Dr. Andrew A. Pieper, Harrington Discovery Institute Director of Neurotherapeutic Discovery. “We bridge the gap between academia, where many great medical ideas are born, and industry, where these ideas can be guided through the costly and complex process of transforming them into new medicines for patients.”

Vanderbilt University principal investigator Jerri Rook, Ph.D. and her Vanderbilt University Medical Center physician collaborator Dr. Paul Newhouse received the 2015 ADDF-Harrington Scholar Award. The award provided funding and expertise in formulation and interpretation of safety pharmacology and toxicology data from experienced drug development professionals.

The compounds covered by the agreement work by activating muscarinic M1 receptors in the brain in a unique way that increases their responsiveness to a neurotransmitter called acetylcholine, which plays a critical role in regulating memory and cognition.

“We are excited about the commercial support for the important work of Dr. Rook and her colleagues that we hope will lead to an effective and safe treatment for people with Alzheimer’s disease,” said Dr. Howard Fillit, ADDF Founding Executive Director and Chief Science Officer.

As explained by Dr. Rook, researchers have long theorized that this mechanism could effectively treat memory loss in Alzheimer’s disease and other brain disorders, but intolerable side effects have barred their use—at least so far. “Our focus has been on discovering and developing compounds that have the desired treatment benefits without the unwanted side effects. We have now optimized this in a mouse model of Alzheimer’s disease and are very much looking forward to seeing how they perform in human studies,” said Dr. Rook. The lead compound has entered Phase I clinical trials with support from the ADDF.

About the Alzheimer’s Drug Discovery Foundation (ADDF)

The Alzheimer’s Drug Discovery Foundation is the only public charity solely focused on funding the development of drugs for Alzheimer’s disease, employing a venture philanthropy model to support research in academia and the biotech industry. Through the generosity of its donors, the ADDF has awarded more than $150 million to fund over 626 Alzheimer’s drug discovery programs and clinical trials in 19 countries. To learn more, please visit:

About the Harrington Discovery Institute

The Harrington Discovery Institute at University Hospitals in Cleveland, Ohio—part of The Harrington Project for Discovery & Development—aims to advance medicine and society by enabling the most inventive scientists to turn their discoveries into medicines that improve human health. The Institute was created in 2012 with a $50 million founding gift from the Harrington family and instantiates the commitment they share with University Hospitals to a Vision for a “Better World.”

SOURCE Alzheimer’s Drug Discovery Foundation

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