Posts Tagged ‘North Carolina’

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After passing legislation 6 years ago that prohibited North Carolina policymakers from considering climate change data in planning for rising sea levels along their coast, Hurricane Florence now threatens to cause a devastating storm surge that could put thousands of lives in danger and cost North Carolina billions of dollars worth of damage.

The hurricane, which is expected to make landfall on Friday, is shaping up to be one of the worst storms to hit the East Coast. Residents of North Carolina’s Outer Banks and mainland coasts have already been ordered to evacuate. President Donald Trump declared a state of emergency in both North and South Carolina, and a Federal Emergency Management Agency administrator said that the Category 4 hurricane will likely cause “massive damage to our country.”

And the rise in sea levels, experts say, is making the storm surge worse.

Sea level rise is a direct consequence of global warming; the warming of the ocean has resulted in thermal expansion and melted ice sheets and glaciers that are causing the oceans to rise. Since 1950, the sea level has risen 6.5 inches ― a number that sounds small but has actually had major consequences across the country.

“Sea level rising, simply put, makes every coastal flood deeper and more destructive,” said Ben Strauss, CEO of Climate Central, a climate change research organization that has published dozens of studies about rising sea levels and the risks of ignoring the problem. “Ignoring it is incredibly dangerous.”

“It only takes a few extra inches of water depth to be the difference between a ruined floor and no damage, or a ruined electrical system and just a ruined floor,” Strauss said. “Floods tend to be a great deal more destructive and costly than homeowners anticipate.”

Sea level rise can also affect the severity of hurricanes, said William Sweet, an oceanographer at the National Oceanic and Atmospheric Administration. “If you compared storm surge heights from the same storm at the same location over several decades, the surge would be higher ― assuming no change in flood defenses ― because of sea level rise,” Sweet said.

But in North Carolina, lawmakers chose to ignore the threats. A panel of scientists on the state Coastal Resources Commission issued a dire warning in March 2010, estimating that the sea levels along the state’s coast would rise 39 inches over the next century. Conservative lawmakers and business interest groups feared the report would hurt lucrative real estate development on the state’s coast and sought to undermine it. A lobbying group committed to economic development on the coast accused the panel of “pulling data out of their hip pocket.”

Conservative state Rep. Pat McElraft, whose top campaign contributors were the North Carolina Association of Realtors and the North Carolina Home Builders’ Association, drafted a bill in response that rejected the panel’s predictions.

McElraft introduced the bill in April 2011, and it passed the legislature in the summer of 2012.

Part of the bill stipulated that state and local agencies must also refer to historical linear predictions of sea level rise rather than current research, and another alarming section required that research look only at 30-year predictions rather than at a century, as the CRC report had done. Supporters of the bill saw short-term benefits in more affordable insurance, and continued opportunities for real estate development and tourism along the attractive coast. Critics saw the long-term consequences of damaged homes and businesses and vast swaths of the state being swallowed by floods.

Environmental scientists, coastal researchers and a number of lawmakers called the measure a blatant denial of crucial climate science and criticized then-Gov. Bev Perdue (D) for not acting on the bill and therefore allowing it to become law.

“By putting our heads in the sand, literally, we are not helping property owners,” said then-state Sen. Deborah K. Ross. “We are hurting them. We are not giving them information they might need to protect their property. Ignorance is not bliss. It’s dangerous.”

‘It’s a really bad setup’

In North Carolina, the state’s topography and the rising sea levels have made for even more dangerous storms and floods, Strauss said. Unlike coastal communities that have deep, cliff-like dropoffs, North Carolina’s coast is flat, wide and shallow, “like a kiddie pool,” Strauss said. “When you think about storm surge, some places have higher potential than others. The same storm would produce different surges depending on the topography,” said Strauss.

The state also has a wide, shallow continental shelf compared with places like Miami, which “means there is massive potential for a storm surge,” he said.

“Especially a storm like this, that’s moving straight forward,” he said. “It’s a really bad setup.”

At the same time, climate change has “supercharged” recent storms, as HuffPost’s Chris D’Angelo reported on Friday, putting Florence on track to do as much, if not more, damage than last year’s Hurricane Harvey, which devastated parts of Texas and Louisiana.

“It is fair to say that the very same factors are likely at play here, namely very warm ocean temperatures and an anomalous jet stream pattern favoring stalled weather systems,” said Michael Mann, a climate scientist at Pennsylvania State University.

https://www.huffingtonpost.com/entry/north-carolina-sea-level-rise-hurricane-florence_us_5b985a87e4b0162f4731da0e?ncid=APPLENEWS00001

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Penises grown in laboratories could soon be tested on men by scientists developing technology to help people with congenital abnormalities, or who have undergone surgery for aggressive cancer or suffered traumatic injury.

Researchers at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, North Carolina, are assessing engineered penises for safety, function and durability. They hope to receive approval from the US Food and Drug Administration and to move to human testing within five years.

Professor Anthony Atala, director of the institute, oversaw the team’s successful engineering of penises for rabbits in 2008. “The rabbit studies were very encouraging,” he said, “but to get approval for humans we need all the safety and quality assurance data, we need to show that the materials aren’t toxic, and we have to spell out the manufacturing process, step by step.”

The penises would be grown using a patient’s own cells to avoid the high risk of immunological rejection after organ transplantation from another individual. Cells taken from the remainder of the patient’s penis would be grown in culture for four to six weeks.

For the structure, they wash a donor penis in a mild detergent to remove all donor cells. After two weeks a collagen scaffold of the penis is left, on to which they seed the patient’s cultured cells – smooth muscle cells first, then endothelial cells, which line the blood vessels. Because the method uses a patient’s own penis-specific cells, the technology will not be suitable for female-to-male sex reassignment surgery.

“Our target is to get the organs into patients with injuries or congenital abnormalities,” said Atala, whose work is funded by the US Armed Forces Institute of Regenerative Medicine, which hopes to use the technology to help soldiers who sustain battlefield injuries.

As a paediatric urological surgeon, Atala began his work in 1992 to help children born with genital abnormalities. Because of a lack of available tissue for reconstructive surgery, baby boys with ambiguous genitalia are often given a sex-change at birth, leading to much psychological anguish in later life. “Imagine being genetically male but living as a woman,” he said. “It’s a firmly devastating problem that we hope to help with.”

Asif Muneer, a consultant urological surgeon and andrologist at University College hospital, London, said the technology, if successful, would offer a huge advance over current treatment strategies for men with penile cancer and traumatic injuries. At present, men can have a penis reconstructed using a flap from their forearm or thigh, with a penile prosthetic implanted to simulate an erection.

“My concern is that they might struggle to recreate a natural erection,” he said. “Erectile function is a coordinated neurophysiological process starting in the brain, so I wonder if they can reproduce that function or whether this is just an aesthetic improvement. That will be their challenge.”

Atala’s team are working on 30 different types of tissues and organs, including the kidney and heart. They bioengineered and transplanted the first human bladder in 1999, the first urethra in 2004 and the first vagina in 2005.

Professor James Yoo, a collaborator of Atala’s at Wake Forest Institute, is working on bioengineering and replacing parts of the penis to help treat erectile dysfunction. His focus is on the spongy erectile tissue that fills with blood during an erection, causing the penis to lengthen and stiffen. Disorders such as high blood pressure and diabetes can damage this tissue, and the resulting scar tissue is less elastic, meaning the penis cannot fill fully with blood.

“If we can engineer and replace this tissue, these men can have erections again,” said Yoo, acknowledging the many difficulties. “As a scientist and clinician, it’s this possibility of pushing forward current treatment practice that really keeps you awake at night.”

http://www.theguardian.com/science/2014/oct/05/laboratory-penises-test-on-men