Satellites can predict famine before it occurs


Hundred of miles about Earth, orbiting satellites are becoming a bold new weapon in the age-old fight against drought, disease and death.

By Ariel Sabar
SMITHSONIAN MAGAZINE

In early October, after the main rainy season, Ethiopia’s central Rift Valley is a study in green. Fields of wheat and barley lie like shimmering quilts over the highland ridges. Across the valley floor below, beneath low-flying clouds, farmers wade through fields of African cereal, plucking weeds and primping the land for harvest

It is hard to look at such lushness and equate Ethiopia with famine. The f-word, as some people call it, as though the mere mention were a curse, has haunted the country since hundreds of thousands of Ethiopians died three decades ago in the crisis that inspired Live Aid, “We Are the World” and other spectacles of Western charity. The word was on no one’s lips this year. Almost as soon as I’d landed in Addis Ababa, people told me that 2014 had been a relatively good year for Ethiopia’s 70 million subsistence farmers.

But Gabriel Senay wasn’t so sure. A scientist with the U.S. Geological Survey, he’d designed a system that uses NASA satellites to detect unusual spikes in land temperature. These anomalies can signal crop failure, and Senay’s algorithms were now plotting these hot zones along a strip of the Rift Valley normally thought of as a breadbasket. Was something amiss? Something aid workers hadn’t noticed?

Senay had come to Ethiopia to find out—to “ground-truth” his years of painstaking research. At the top of a long list of people eager for results were officials at the U.S. Agency for International Development, who had made a substantial investment in his work. The United States is the largest donor of food aid to the world, splitting $1.5 billion to $2.5 billion a year among some 60 countries in Africa, Asia and Latin America. Ethiopia usually gets the biggest slice, but it’s a large pie, and to make sure aid gets to the neediest, USAID spends $25 million a year on scientific forecasts of where hunger will strike next.

Senay’s innovations, some officials felt, had the potential to take those forecasts to a new level, by spotting the faintest first footsteps of famine almost anywhere in the world. And the earlier officials heard those footsteps, the faster they would be able to mobilize forces against one of humanity’s oldest and cruelest scourges.

In the paved and wired developed world, it’s hard to imagine a food emergency staying secret for long. But in countries with bad roads, spotty phone service and shaky political regimes, isolated food shortfalls can metastasize into full-blown humanitarian crises before the world notices. That was in many ways the case in Ethiopia in 1984, when the failure of rains in the northern highlands was aggravated by a guerrilla war along what is now the Eritrean border.

Senay, who grew up in Ethiopian farm country, the youngest of 11 children, was then an undergraduate at the country’s leading agricultural college. But the famine had felt remote even to him. The victims were hundreds of miles to the north, and there was little talk of it on campus. Students could eat injera—the sour pancake that is a staple of Ethiopian meals—just once a week, but Senay recalls no other hardships. His parents were similarly spared; the drought had somehow skipped over their rainy plateau.

That you could live in one part of a country and be oblivious to mass starvation in another: Senay would think about that a lot later.

The Great Rift Valley splits Ethiopia into nearly equal parts, running in a ragged diagonal from the wastelands of the Danakil Depression in the northeast to the crocodile haunts of Lake Turkana in the southwest. About midway along its length, a few hours’ drive south of Addis, it bisects a verdant highland of cereal fields.

Senay, who is 49, sat in the front seat of our Land Cruiser, wearing a baseball cap lettered, in cursive, “Life is Good.” Behind us were two other vehicles, shuttling half a dozen American and Ethiopian scientists excited enough by Senay’s research to want to see its potential firsthand. We caravanned through the gritty city of Adama and over the Awash River, weaving through cavalcades of donkeys and sheep.

Up along the green slopes of the Arsi highlands, Senay looked over his strangely hued maps. The pages were stippled with red and orange dots, each a square kilometer, where satellites 438 miles overhead had sensed a kind of fever on the land.

From the back seat, Curt Reynolds, a burly crop analyst with the U.S. Department of Agriculture in Washington, who advises USAID (and is not known to sugar-coat his opinions), asked whether recent rains had cooled those fevers, making some of Senay’s assessments moot. “There are still pixels that are really hurting,” Senay insisted.

We turned off the main road, jouncing along a muddy track to a local agricultural bureau. Huseen Muhammad Galatoo, a grave-looking man who was the bureau’s lead agronomist, led us into a musty office. A faded poster on one wall said, “Coffee: Ethiopia’s Gift to the World.”

Galatoo told us that several Arsi districts were facing their worst year in decades. A failure of the spring belg rains and a late start to the summer kiremt rains had left some 76,000 animals dead and 271,000 people—10 percent of the local population—in need of emergency food aid.

“Previously, the livestock used to survive somehow,” Galatoo said, through an interpreter. “But now there is literally nothing on the ground.”

In the face of such doleful news, Senay wasn’t in the mood for self-congratulation. But the truth was, he’d nailed it. He’d shown that satellites could spot crop failure—and its effects on livestock and people—as never before, at unprecedented scale and sensitivity. “The [current] early warning system didn’t fully capture this,” Alemu Asfaw, an Ethiopian economist who helps USAID forecast food crises, said in the car afterwards, shaking his head. “There had been reports of erratic rainfall. But no one expected it to be that bad.” No one, that is, but Senay, whose work, Reynolds said, could be “a game changer for us.”

Satellites have come a long way since Russia’s Sputnik 1—a beachball-size sphere with four chopstick-like radio antennas—entered orbit, and history, in 1957. Today, some 1,200 artificial satellites orbit Earth. Most are still in traditional lines of work: bouncing phone calls and television signals across the globe, beaming GPS coordinates, monitoring weather, spying. A smaller number watch over the planet’s wide-angle afflictions, like deforestation, melting glaciers and urban sprawl. But only recently have scientists sicced satellites on harder-to-detect, but no less perilous threats to people’s basic needs and rights.

Senay is on the leading edge of this effort, focusing on hunger and disease—ills whose solutions once seemed resolutely earthbound. Nomads searching for water, villagers battling malaria, farmers aching for rain: When they look to the heavens for help, Senay wants satellites looking back.

He was born in the northwest Ethiopian town of Dangila, in a house without electricity or plumbing. To cross the local river with his family’s 30 cattle, little Gabriel clung to the tail of an ox, which towed him to the grazing lands on the other side. High marks in school—and a father who demanded achievement, who called Gabriel “doctor” while the boy was still in diapers—propelled him to Ethiopia’s Haramaya University and then to the West, for graduate studies in hydrology and agricultural engineering.

Not long after earning a PhD at Ohio State University, he landed a job that felt more like a mission—turning American satellites into defenders of Africa’s downtrodden. His office, in the South Dakota countryside 18 miles northeast of Sioux Falls, is home to the Earth Resources Observation and Science Center, a low building, ringed by rows of tinted windows, looking a bit like a spaceship that emergency-landed in some hapless farmer’s corn and soybean spread. Run by the U.S. Geological Survey, it’s where the planet gets a daily diagnostic exam. Giant antennas and parabolic dishes ingest thousands of satellite images a day, keeping an eye on the pulse of the planet’s waters, the pigment of its land and the musculature of its mountains.

Senay was soon living the American dream, with a wife, two kids and mini­van in a Midwestern suburb. But satellites were his bridge home, closing the distance between here and there, now and then. “I came to know more about Ethiopia in South Dakota when looking at it from satellites than I did growing up,” he told me. As torrents of data flow through his calamity-spotting algorithms, he says, “I imagine the poor farmer in Ethiopia. I imagine a guy struggling to farm who never got a chance to get educated, and that kind of gives me energy and some bravery.”

His goal from the outset was to turn satellites into high-tech divining rods, capable of finding water—and mapping its effects—across Africa. Among scientists who study water’s whereabouts, Senay became a kind of rock star. Though nominally a bureaucrat in a remote outpost of a federal agency, he published in academic journals, taught graduate-level university courses and gave talks in places as far-flung as Jordan and Sri Lanka. Before long, people were calling from all over, wanting his algorithms for their own problems. Could he look at whether irrigation in Afghanistan’s river basins was returning to normal after years of drought and war? What about worrisome levels of groundwater extraction in America’s Pacific Northwest? Was he free for the National Water Census?

He’d started small. A man he met on a trip to Ethiopia told him that 5,200 people had died of malaria in three months in a single district in the Amhara region. Senay wondered if satellites could help. He requested malaria case data from clinics across Amhara and then compared them with satellite readings of rainfall, land greenness and ground moisture—all factors in where malaria-carrying mosquitoes breed. And there it was, almost like magic: With satellites, he could predict the location, timing and severity of malaria outbreaks up to three months in advance. “For prevention, early warning is very important for us,” Abere Mihretie, who leads an anti-malaria group in Amhara, told me. With $2.8 million from the National Institutes of Health, Senay and Michael Wimberly, an ecologist at South Dakota State University, built a website that gives Amhara officials enough early warning to order bed nets and medicines and to take preventive steps such as draining standing water and counseling villagers. Mihretie expects the system—which will go live this year—to be a lifesaver, reducing malaria cases by 50 to 70 percent.

Senay had his next epiphany on a work trip to Tanzania in 2005. By the side of the road one day, he noticed cattle crowding a badly degraded water hole. It stirred memories of childhood, when he’d watched cows scour riverbeds for trickles of water. The weakest got stuck in the mud, and Senay and his friends would pull them out. “These were the cows we grew up with, who gave us milk,” he says. “You felt sorry.”

Senay geo-tagged the hole in Tanzania, and began reading about violent conflict among nomadic clans over access to water. One reason for the conflicts, he learned, was that nomads were often unaware of other, nearby holes that weren’t as heavily used and perhaps just as full of water.

Back in South Dakota, Senay found he could see, via satellite, the particular Tanzania hole he’d visited. What’s more, it gave off a distinct “spectral signature,” or light pattern, which he could then use to identify other water holes clear across the African Sahel, from Somalia to Mali. With information about topography, rainfall estimates, temperature, wind speed and humidity, Senay was then able to gauge how full each hole was.

Senay and Jay Angerer, a rangeland ecologist at Texas A&M University, soon won a $1 million grant from NASA to launch a monitoring system. Hosted on a U.S. Geological Survey website, it tracks some 230 water holes across Africa’s Sahel, giving each a daily rating of “good,” “watch,” “alert” or “near dry.” To get word to herders, the system relies on people like Sintayehu Alemayehu, of the aid group Mercy Corps. Alemayehu and his staff meet with nomadic clans at village markets to relay a pair of satellite forecasts—one for water-hole levels, another for pasture conditions. But such liaisons may soon go the way of the switchboard operator. Angerer is seeking funding for a mobile app that would draw on a phone’s GPS to lead herders to water. “Sort of like Yelp,” he told me.

Senay was becoming a savant of the data workaround, of the idea that good enough is sometimes better than perfect. Doppler radar, weather balloons, dense grids of electronic rain gauges simply don’t exist in much of the developing world. Like some MacGyver of the outback, Senay was proving an “exceptionally good detective” in finding serviceable replacements for laboratory-grade data, says Andrew Ward, a prominent hydrologist who was Senay’s dissertation adviser at Ohio State. In remote parts of the world, Ward says, even good-enough data can go a long way toward “helping solve big important issues.”

And no issue was more important to Senay than his homeland’s precarious food supply.

Ethiopia’s poverty rate is falling, and a new generation of leaders has built effective programs to feed the hungry in lean years. But other things have been slower to change: 85 percent of Ethiopians work the land as farmers or herders, most at the subsistence level, and less than 1 percent of agricultural land is irrigated. That leaves Ethiopia, the second most populous country in Africa, at the mercy of the region’s notoriously fickle rains. No country receives more global food aid.

Famine appears in Ethiopia’s historical record as early as the ninth century and recurs with an almost tidal regularity. The 1973 famine, which killed tens of thousands, led to the overthrow of Emperor Haile Selassie and the rise of an insurgent Marxist government known as the Derg. The 1984 famine helped topple the Derg.

Famine often has multiple causes: drought, pestilence, economies overdependent on agriculture, antiquated farming methods, geographic isolation, political repression, war. But there was a growing sense in the latter decades of the 20th century that science could play a role in anticipating—and heading off—its worst iterations. The United Nations started a basic early-warning program in the mid-1970s, but only after the 1980s Ethiopian crisis was a more rigorously scientific program born: USAID’s Famine Early Warning Systems Network (FEWS NET).

Previously, “a lot of our information used to be from Catholic priests in, like, some little mission in the middle of Mali, and they’d say, ‘My people are starving,’ and you’d kind of go, ‘Based on what?’” Gary Eilerts, a veteran FEWS NET official, told me. Missionaries and local charities could glimpse conditions outside their windows, but had little grasp of the broader severity and scope of suffering. Local political leaders had a clearer picture, but weren’t always keen to share it with the West, and when they did, the West didn’t always trust them.

The United States needed hard, objective data, and FEWS NET was tasked with gathering it. To complement their analyses of food prices and economic trends, FEWS NET scientists did use satellites, to estimate rainfall and monitor land greenness. But then they heard about a guy in small-town South Dakota who looked like he was going one better.

Senay knew that one measure of crop health was the amount of water a field gave off: its rate of “evapotranspiration.” When plants are thriving, water in the soil flows up roots and stems into leaves. Plants convert some of the water to oxygen, in photosynthesis. The rest is “transpired,” or vented, through pores called stomata. In other words, when fields are moist and crops are thriving, they sweat.

Satellites might not be able to see the land sweat, but Senay wondered if they could feel it sweat. That’s because when water in soil or plants evaporates, it cools the land. Conversely, when a lush field takes a tumble—whether from drought, pests or neglect—evapotranspiration declines and the land heats. Once soil dries to the point of hardening and cracking, its temperature is as much as 40 degrees hotter than it was as a well-watered field.

NASA’s Aqua and Terra satellites carry infrared sensors that log the temperature of every square kilometer of earth every day. Because those sensors have been active for more than a decade, Senay realized that a well-crafted algorithm could flag plots of land that got suddenly hotter than their historical norm. In farming regions, these hotspots could be bellwethers of trouble for the food supply.

Scientists had studied evapotranspiration with satellites before, but their methods were expensive and time-consuming: Highly paid engineers had to manually interpret each snapshot of land. That’s fine if you’re interested in one tract of land at one point in time.

But what if you wanted every stitch of farmland on earth every day? Senay thought he could get there with a few simplifying assumptions. He knew that when a field was perfectly healthy—and thus at peak sweat—land temperature was a near match for air temperature. Senay also knew that a maximally sick field was a fixed number of degrees hotter than a maximally healthy one, after tweaking for terrain type.

So if he could get air temperature for each square kilometer of earth, he’d know the coldest the land there could be at that time. By adding that fixed number, he’d also know the hottest it could be. All he needed now was ­NASA’s actual reading of land temperature, so he could see where it fell within those theoretical extremes. That ratio told you how sweaty a field was—and thus how healthy.

Senay found good air temperature datasets at the National Oceanic and Atmospheric Administration and the University of California, Berkeley. By braiding the data from NASA, NOAA and Berkeley, he could get a computer to make rapid, automated diagnoses of crop conditions anywhere in the world. “It’s data integration at the highest level,” he told me one night, in the lobby of our Addis hotel.

The results might be slightly less precise than the manual method, which factors in extra variables. But the upsides—how much of the world you saw, how fast you saw it, how little it cost—wasn’t lost on his bosses. “Some more academically oriented people reach an impasse: ‘Well, I don’t know that, I can’t assume that, therefore I’ll stop,’” says James Verdin, his project leader at USGS, who was with us in the Rift Valley. “Whereas Gabriel recognizes that the need for an answer is so strong that you need to make your best judgment on what to assume and proceed.” FEWS NET had just one other remote test of crop health: satellites that gauge land greenness. The trouble is that stressed crops can stay green for weeks, before shading brown. Their temperature, on the other hand, ticks up almost immediately. And unlike the green test, which helps only once the growing season is underway, Senay’s could read soil moisture at sowing time.

The Simplified Surface Energy Balance model, as it is called, could thus give officials and aid groups several weeks’ more lead time to act before families would go hungry and livestock would begin to die. Scientists at FEWS NET’s Addis office email their analyses to 320 people across Ethiopia, including government officials, aid workers and university professors.

Biratu Yigezu, acting director general of Ethiopia’s Central Statistical Agency, told me that FEWS NET fills key blanks between the country’s annual door-to-door surveys of farmers. “If there’s a failure during planting stage, or if there’s a problem in the flowering stage, the satellites help, because they’re real time.”

One afternoon in the Rift Valley, we pulled the Land Cruisers alongside fields of slouching corn to speak with a farmer. Tegenu Tolla, who was 35, wore threadbare dress pants with holes at the knees and a soccer jersey bearing the logo of the insurance giant AIG. He lives with his wife and three children on whatever they can grow on their two and a half acre plot.

This year was a bust, Tolla told Senay, who chats with farmers in his native Amharic. “The rains were not there.” So Tolla waited until August, when some rain finally came, and sowed a short-maturing corn with miserly yields. “We will not even be able to get our seeds back,” Tolla said. His cattle had died, and to feed his family, Tolla had been traveling to Adama for day work on construction sites.

We turned onto a lumpy dirt road, into a field where many of the teff stalks had grown just one head instead of the usual six. (Teff is the fine grain used to make injera.) Gazing at the dusty, hard-packed soil, Senay had one word: “desertification.”

The climate here was indeed showing signs of long-term change. Rainfall in the south-central Rift Valley has dropped 15 to 20 percent since the mid-1970s, while the population—the number of mouths to feed—has mushroomed. “If these trends persist,” FEWS NET wrote in a 2012 report, they “could leave millions more Ethiopians exposed to hunger and undernourishment.”

Over the next few days we spiraled down from the highlands into harder-hit maize-growing areas and finally into scrublands north of the Kenyan border, a place of banana plantations and roadside baboons and throngs of cattle, which often marooned our vehicles. At times, the road seemed a province less of autos than of animals and their child handlers. Boys drove battalions of cows and sheep, balanced jerrycans of water on their shoulders and stood atop stick-built platforms in sorghum fields, flailing their arms to scare off crop-devouring queleas, a type of small bird.

Almost everywhere we stopped we found grim alignments between the red and orange dots on Senay’s maps and misery on the ground. Senay was gratified, but in the face of so much suffering, he wanted to do more. Farmers knew their own fields so well that he wondered how to make them players in the early warning system. With a mobile app, he thought, farmers could report on the land beneath their feet: instant ground-truthing that could help scientists sharpen their forecasts.

What farmers lacked was the big picture, and that’s what an app could give back: weather predictions, seasonal forecasts, daily crop prices in nearby markets. Senay already had a name: Satellite Integrated Farm Information, or SIFI. With data straight from farmers, experts in agricultural remote sensing, without ever setting foot on soil, would be a step closer to figuring out exactly how much food farmers could coax from the land.

But soil engulfed us now—it was in our boots, beneath our fingernails—and there was nothing to do but face farmers eye to eye.

“Allah, bless this field,” Senay said to a Muslim man, who’d told us of watching helplessly as drought killed off his corn crop.

“Allah will always bless this field,” the man replied. “We need something more.”

Read more: http://www.smithsonianmag.com/innovation/predict-famine-before-strikes-180954945/#AH5TUUitTQLjlkuI.99

Chef Massimo Bottura on Why the Future of Food is in Our Trash

By MASSIMO BOTTURA

WHEN I THINK ABOUT THE FUTURE of restaurants—what chefs will be cooking in the years to come—the first thing that comes to mind is garbage: day-old bread, potato peels, fish bones, wilted vegetables. We currently produce enough food to feed the world’s 7.3 billion people, and yet 795 million are hungry, according to the United Nations. The reason is waste: a 2013 U.N. report reveals that 550 million tons of food are discarded by distributors, supermarkets and consumers every year. The U.S. and EU have pledged to reduce food waste in the next 10 to 15 years. This is where chefs come in.

This year the 20th anniversary of my restaurant, Osteria Francescana, coincided with the Expo Milano 2015. In an effort to address the expo’s ambitious theme—“Feeding the Planet, Energy for Life”—Francescana collaborated with the Catholic charity Caritas Ambrosiana and the culture maven Davide Rampello to turn a renovated theater in the Greco quarter into a think tank and experimental soup kitchen. This collaboration was baptized Refettorio Ambrosiano after Sant’Ambrogio, Milan’s patron saint. The word Refettorio has roots in the Latin word refice, to restore, and Refettorio Ambrosiano runs on salvaged waste and volunteer labor, including stints from the best chefs in the world.

In May, Daniel Humm of Eleven Madison Park made a sweet pudding from day-old, discarded bread. In June, René Redzepi of Noma turned black bananas into mouth-watering banana bread. In July, Daniel Patterson of Coi produced the quintessential minestrone from a crate of dismal-looking vegetables. Osteria Francescana made weekly broths from vegetable scraps and peelings. The guests were not fine-dining regulars, but a selection of Milan’s homeless community. What surprised us all was just how fabulous salvaged food can become.

Every Refettorio Ambrosiano recipe is an ode to imperfection with revolutionary potential; these dishes could change the way we feed the world, because they can be cooked by anyone, anywhere, on any budget. For families in need, it’s a way to bring dignity back to the table—dignity based not on the quality of ingredients, but on the quality of ideas.

Chefs have greater social responsibility than ever before. Celebrity status has allowed some of us to become ambassadors of culture and advocates for artisans, ethics and change. But have we spent enough time and energy considering the waste that results from our work? Imagine a school where young chefs are taught to be as resourceful with ingredients as they are with ideas. Imagine chefs embracing imperfect, discarded food and treating it with the same reverence they would a rack of lamb or ripe tomato. Imagine changing the perceptions about what is beautiful, nutritious and worthy of being shared.

Cooking is a call to act. At its best it can unite, revive and restore. As populations grow and food supplies are threatened, we are called to educate and spread ideas that will be the motivational force behind the evolution of our kitchens, our communities and our future. Let us begin by turning our waste—in our homes and our restaurants—into food that’s ethical and delicious. Because something salvaged is something gained.

http://www.wsj.com/articles/chef-massimo-bottura-on-why-the-future-of-food-is-in-our-trash-1449506020

Exploring the Biology of Eating Disorders

With the pressure for a certain body type prevalent in the media, eating disorders are on the rise. But these diseases are not completely socially driven; researchers have uncovered important genetic and biological components as well and are now beginning to tease out the genes and pathways responsible for eating disorder predisposition and pathology.

As we enter the holiday season, shoppers will once again rush into crowded department stores searching for the perfect gift. They will be jostled and bumped, yet for the most part, remain cheerful because of the crisp air, lights, decorations, and the sound of Karen Carpenter’s contralto voice ringing out familiar carols.

While Carpenter is mainly remembered for her musical talents, unfortunately, she is also known for introducing the world to anorexia nervosa (AN), a severe life-threatening mental illness characterized by altered body image and stringent eating patterns that claimed her life just before her 33rd birthday in 1983.

Even though eating disorders (ED) carry one of the highest mortality rates of any mental illness, many researchers and clinicians still view them as socially reinforced behaviors and diagnose them based on criteria such as “inability to maintain body weight,” “undue influence of body weight or shape on self-evaluation,” and “denial of the seriousness of low body weight” (1). This way of thinking was prevalent when Michael Lutter, then an MD/PhD student at the University of Texas Southwestern Medical Center, began his psychiatry residency in an eating disorders unit. “I just remember the intense fear of eating that many patients exhibited and thought that it had to be biologically driven,” he said.

Lutter carried this impression with him when he established his own research laboratory at the University of Iowa. Although clear evidence supports the idea that EDs are biologically driven—they predominantly affect women and significantly alter energy homeostasis—a lack of well-defined animal models combined with the view that they are mainly behavioral abnormalities have hindered studies of the neurobiology of EDs. Still, Lutter is determined to find the biological roots of the disease and tease out the relationship between the psychiatric illness and metabolic disturbance using biochemistry, neuroscience, and human genetics approaches.

We’ve Only Just Begun

Like many diseases, EDs result from complex interactions between genes and environmental risk factors. They tend to run in families, but of course, for many family members, genetics and environment are similar enough that teasing apart the influences of nature and nurture is not easy. Researchers estimate that 50-80% of the predisposition for developing an ED is genetic, but preliminary genome-wide analyses and candidate gene studies failed to identify specific genes that contribute to the risk.

According to Lutter, finding ED study participants can be difficult. “People are either reluctant to participate, or they don’t see that they have a problem,” he reported. Set on finding the genetic underpinnings of EDs, his team began recruiting volunteers and found 2 families, 1 with 20 members, 10 of whom had an ED and another with 5 out of 8 members affected. Rather than doing large-scale linkage and association studies, the team decided to characterize rare single-gene mutations in these families, which led them to identify mutations in the first two genes, estrogen-related receptor α (ESRRA) and histone deacetylase 4 (HDAC4), that clearly associated with ED predisposition in 2013 (1).

“We have larger genetic studies on-going, including the collection of more families. We just happened to publish these two families first because we were able to collect enough individuals and because there is a biological connection between the two genes that we identified,” Lutter explained.

ESRRA appears to be a transcription factor upregulated by exercise and calorie restriction that plays a role in energy balance and metabolism. HDAC4, on the other hand, is a well-described histone deacteylase that has previously been implicated in locomotor activity, body weight homeostasis, and neuronal plasticity.

Using immunoprecipitation, the researchers found that ESRRA interacts with HDAC4, in both the wild type and mutant forms, and transcription assays showed that HDAC4 represses ESRRA activity. When Lutter’s team repeated the transcription assays using mutant forms of the proteins, they found that the ESRRA mutation seen in one family significantly reduced the induction of target gene transcription compared to wild type, and that the mutation in HDAC4 found in the other family increased transcriptional repression for ESRRA target genes.

“ESRRA is a well known regulator of mitochondrial function, and there is an emerging view that mitochondria in the synapse are critical for neurotransmission,” Lutter said. “We are working on identifying target pathways now.”

Bless the Beasts and the Children

Finding genes associated with EDs provides the groundwork for molecular studies, but EDs cannot be completely explained by the actions of altered transcription factors. Individuals suffering these disorders often experience intense anxiety, intrusive thoughts, hyperactivity, and poor coping strategies that lead to rigid and ritualized behaviors and severe crippling perfectionism. They are less aware of their emotions and often try to avoid emotion altogether. To study these complex behaviors, researchers need animal models.

Until recently, scientists relied on mice with access to a running wheel and restricted access to food. Under these conditions, the animals quickly increase their locomotor activity and reduce eating, frequently resulting in death. While some characteristics of EDs—excessive exercise and avoiding food—can be studied in these mice, the model doesn’t allow researchers to explore how the disease actually develops. However, Lutter’s team has now introduced a promising new model (3).

Based on their previous success with identifying the involvement of ESRRA and HDAC4 in EDs, the researchers wondered if mice lacking ESRRA might make suitable models for studies on ED development. To find out, they first performed immunohistochemistry to understand more about the potential cognitive role of ESRRA.

“ESRRA is not expressed very abundantly in areas of the brain typically implicated in the regulation of food intake, which surprised us,” Lutter said. “It is expressed in many cortical regions that have been implicated in the etiology of EDs by brain imaging like the prefrontal cortex, orbitofrontal cortex, and insula. We think that it probably affects the activity of neurons that modulate food intake instead of directly affecting a core feeding circuit.”

With these data, the team next tried providing only 60% of the normal daily calories to their mice for 10 days and looked again at ESRRA expression. Interestingly, ESRRA levels increased significantly when the mice were insufficiently fed, indicating that the protein might be involved in the response to energy balance.

Lutter now believes that upregulation of ESRRA helps organisms adapt to calorie restriction, an effect possibly not happening in those with ESRRA or HDAC4 mutations. “This makes sense for the clinical situation where most individuals will be doing fine until they are challenged by something like a diet or heavy exercise for a sporting event. Once they start losing weight, they don’t adapt their behaviors to increase calorie intake and rapidly spiral into a cycle of greater and greater weight loss.”

When Lutter’s team obtained mice lacking ESRRA, they found that these animals were 15% smaller than their wild type littermates and put forth less effort to obtain food both when fed restricted calorie diets and when they had free access to food. These phenotypes were more pronounced in female mice than male mice, likely due to the role of estrogen signaling. Loss of ESRRA increased grooming behavior, obsessive marble burying, and made mice slower to abandon an escape hole after its relocation, indicating behavioral rigidity. And the mice demonstrated impaired social functioning and reduced locomotion.

Some people with AN exercise extensively, but this isn’t seen in all cases. “I would say it is controversial whether or not hyperactivity is due to a genetic predisposition (trait), secondary to starvations (state), or simply a ritual that develops to counter the anxiety of weight related obsessions. Our data would suggest that it is not due to genetic predisposition,” Lutter explained. “But I would caution against over-interpretation of mouse behavior. The locomotor activity of mice is very different from people and it’s not clear that you can directly translate the results.”

For All We Know

Going forward, Lutter’s group plans to drill down into the behavioral phenotypes seen in their ESRRA null mice. They are currently deleting ESRRA from different neuronal cell types to pair individual neurons with the behaviors they mediate in the hope of working out the neural circuits involved in ED development and pathology.

In addition, the team has created a mouse line carrying one of the HDAC4 mutations previously identified in their genetic study. So far, this mouse “has interesting parallels to the ESRRA-null mouse line,” Lutter reported.

The team continues to recruit volunteers for larger-scale genetic studies. Eventually, they plan to perform RNA-seq to identify the targets of ESRRA and HDAC4 and look into their roles in mitochondrial biogenesis in neurons. Lutter suspects that this process is a key target of ESRRA and could shed light on the cognitive differences, such as altered body image, seen in EDs. In the end, a better understanding of the cells and pathways involved with EDs could create new treatment options, reduce suffering, and maybe even avoid the premature loss of talented individuals to the effects of these disorders.

References

1. Lutter M, Croghan AE, Cui H. Escaping the Golden Cage: Animal Models of Eating Disorders in the Post-Diagnostic and Statistical Manual Era. Biol Psychiatry. 2015 Feb 12.

2. Cui H, Moore J, Ashimi SS, Mason BL, Drawbridge JN, Han S, Hing B, Matthews A, McAdams CJ, Darbro BW, Pieper AA, Waller DA, Xing C, Lutter M. Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. J Clin Invest. 2013 Nov;123(11):4706-13.

3. Cui H, Lu Y, Khan MZ, Anderson RM, McDaniel L, Wilson HE, Yin TC, Radley JJ, Pieper AA, Lutter M. Behavioral disturbances in estrogen-related receptor alpha-null mice. Cell Rep. 2015 Apr 21;11(3):344-50.

http://www.biotechniques.com/news/Exploring-the-Biology-of-Eating-Disorders/biotechniques-361522.html

New research suggests that male brains may be wired to prioritize sex over food.

According to a new study, the male brain contains two extra cells that can cause men to seek out sex as a priority, even over food. Female brains do not contain these cells.

The research, conducted by scientists at University College London, may have been carried out on tiny transparent worms, but co-author Professor Scott Emmons has insisted the findings offer an insight into human sex habits.

“Though the work is carried out in a small worm, it nevertheless gives us a perspective that helps us appreciate and possibly understand the variety of human sexuality, sexual orientation, and gender identification,” he said, according to The Telegraph.

“Although we have not looked in humans, it is plausible that the male human brain has types of neurons that the female brain doesn’t, and vice versa. This may change how the two sexes perceive the world and their behavioural priorities.”

The researchers studied the brains and behaviours of Caenorhabditis elegans – small soil-dwelling worms that grow to 1mm long – to draw their conclusions.

The worm species is made up of two sexes: males and hermaphrodites. Scientists consider the latter “modified females” that do not need to have sex in order to reproduce.

Caenorhabditis elegans are often used in studies relevant to human biology and disease as they contain many of the same genes that humans do.

After recently discovering that the male worms contained two extra brain cells, the researchers wanted to find out what impact this could have on their behaviour.

They conditioned the worms in a controlled environment so that they would associate the appearance of salt with starvation.

Over the course of the experiment, the worms began to move away from the salt.

However, when salt was present at the same time as a potential mate, the male worms risked getting close to the salt in order to advance sexually.

In contrast the hermaphrodite worms continued to move away from the salt.

The study, published in the online journal Nature, concludes that male brains may be genetically wired to prioritise sex over food.

This isn’t the first study to suggest men and women’s brains may be wired differently.

In 2013, a study from the University of Pennsylvania found that men generally have more connections within each hemisphere of the brain, while in women the two halves of the brain are much more interlinked.

The scientists concluded that male brains are mainly configured to co-ordinate perception and action, while women’s are more geared up to integrate “heart and mind” thought processes, linking analytical and intuitive reasoning.

http://www.huffingtonpost.co.uk/2015/10/15/male-brain-prioritise-sex-over-food_n_8300240.html

Defending champion Miki Sudo wins women’s July 4 hot dog eating competition in NYC

Defending champion Miki Sudo captured the women’s division of the annual July Fourth hot dog eating contest at Nathan’s Famous in Coney Island on Saturday with a flourish that emphasized strategy rather than condiments.

The Las Vegas woman ate 38 hot dogs and buns in 10 minutes to claim the title for the second straight year, along with the $10,000 that comes with it.

She retained the coveted mustard yellow winner’s championship belt after downing four more wieners than last year and besting Sonya “Black Widow” Thomas of Alexandria, Virginia, who devoured 31 hot dogs.

Sudo employed a successful strategy of eating the hot dogs separately from the buns and swallowing the buns after first dipping them in Crystal Light.

Here is Miki Sudo practicing her hot dog eating skills.

And here is Miki Sudo eating an eight pound hamburger.

And here she is eating 6 pounds of food in 6 minutes.

And finally, here she is eating pizza.

Many cities in the U.S. are making it illegal for people to give food to people who are homeless

Every Tuesday night, Joan Cheever hits the streets of San Antonio to feed the homeless. In a decade, she’s rarely missed a night. But on a recent, windy Tuesday, something new happens.

The police show up.

“He says we have to have a permit,” Cheever says. “We have a permit. We are a licensed nonprofit food truck.”

Cheever runs a nonprofit called the Chow Train. Her food truck is licensed by the city. On this night, she has loaded the back of a pickup with catering equipment and hot meals and driven to San Antonio’s Maverick Park, near a noisy downtown highway.

Officer Mike Marrota asks to see her permit.

Documents are produced, but there’s a problem: The permit is for the food truck, not her pickup. Cheever argues that the food truck, where she cooks the meals, is too big to drive down the alleyways she often navigates in search of the homeless.

“I tell you guys and the mayor, that we have a legal right to do this,” Cheever says to Marrota.

Marrota asks, “Legal right based on what?”

The Freedom of Religion Restoration Act, Cheever tells him, or RFRA, a federal law which protects free exercise of religion.

The officer isn’t buying it. He writes her a ticket, with a fine of up to $2,000, making clear that San Antonio tickets even good Samaritans if they don’t comply with the letter of the law.

The National Coalition for the Homeless says upwards of 30 cities have some kind of ban on distributing free food for the homeless. Many, including San Antonio, want to consolidate services for the homeless in one location — often, away from tourists.

Does invoking RFRA give Cheever and other good Samaritans license to ignore the law?

“That is not, actually, an easy question to answer,” says Michael Ariens, law professor at St. Mary’s University in San Antonio. “RFRA applies when the government of any type substantially burdens an individual’s free exercise of religion.”

The key phrase is “substantially burdens,” Ariens says.

“RFRA doesn’t allow any do-gooder to simply to do whatever they wish — to make a law onto themselves without interference from local or state government,” he says.

Cheever complains that San Antonio has joined other cities in turning feeding the homeless into a crime.

On the next Tuesday night, Cheever is back in Maverick Park, risking another ticket. She could even be arrested.

But this time there are no police. Cheever and her Chow Train volunteers are greeted by dozens of supporters and homeless people.

“It warms my heart, but it doesn’t surprise me, because the community is behind me and they are behind every other nonprofit that does what I do,” she says.

In late June, Cheever says, she will challenge the ticket in court.

http://www.npr.org/2015/06/13/413988634/when-feeding-the-homeless-runs-afoul-of-the-law