Rare case offers clues to staving off Alzheimer’s

Francisco Lopera, a neurologist at the University of Antioquia in Medellin, Colombia, has been painstakingly collecting brains, birth and death records from one sprawling Colombian family to study Alzheimer’s.Credit…Federico Rios Escobar for The New York Times A woman with lots of beta-amyloid buildup (red) in her brain remained cognitively healthy for decades. by Kelly ServickContinue reading “Rare case offers clues to staving off Alzheimer’s”

China approves 1st new drug for Alzheimer’s disease in 17 years

By Julie Zaugg and Jared Peng Authorities in China have approved a drug for the treatment of Alzheimer’s disease, the first new medicine with the potential to treat the cognitive disorder in 17 years. The seaweed-based drug, called Oligomannate, can be used for the treatment of mild to moderate Alzheimer’s, according to a statement fromContinue reading “China approves 1st new drug for Alzheimer’s disease in 17 years”

Trans Fats, Bad for the Heart, May Be Bad for the Brain as Well

By Nicholas Bakalar Trans fatty acids, known to increase the risk for heart disease, stroke and diabetes, have now been linked to an increased risk for dementia. Researchers measured blood levels of elaidic acid, the most common trans fats, in 1,628 men and women 60 and older and free of dementia. Over the following 10Continue reading “Trans Fats, Bad for the Heart, May Be Bad for the Brain as Well”

Genetic Risk for Alzheimer’s Disease Linked to Highly Active Brains

Young carriers of the APOE4 allele have brains that are more connected (left, red lines illustrate connections between brain areas) and active (right, yellow indicates activity) than the brains of those without the allele. KRISHNA SINGH, ELIFE, 8:E36011, 2019. A growing body of evidence supports the theory that neural hyperactivity and hyperconnectivity precede the pathologicalContinue reading “Genetic Risk for Alzheimer’s Disease Linked to Highly Active Brains”

Retinal screening for Alzheimer’s disease

A technology that originated at the University of Minnesota is well on its way to commercialization thanks to an investment award from Alzheimer’s Drug Discovery Foundation (ADDF). The investment of up to $500,000 was awarded through the ADDF’s Diagnostics Accelerator initiative. Toronto, Ontario-based RetiSpec licensed through the University of Minnesota’s Technology Commercialization program. The technologyContinue reading “Retinal screening for Alzheimer’s disease”

One of the few drugs that has been FDA-approved for patients with Alzheimer’s disease now identified as possibly increasing risk of a life-threatening condition of muscle breakdown

Many people with Alzheimer’s disease take the drug donepezil (brand name Aricept) to help ease symptoms for a time. But those on the drug should be aware of a rare but potentially life-threatening side effect. The drug can cause muscles to break down, leading to a condition called rhabdomyolysis that can lead to kidney damageContinue reading “One of the few drugs that has been FDA-approved for patients with Alzheimer’s disease now identified as possibly increasing risk of a life-threatening condition of muscle breakdown”

Alzheimer’s Directly Kills Brain Cells That Keep You Awake

Brain tissue from deceased patients with Alzheimer’s has more tau protein buildup (brown spots) and fewer neurons (red spots) as compared to healthy brain tissue. By Yasemin Saplakoglu Alzheimer’s disease might be attacking the brain cells responsible for keeping people awake, resulting in daytime napping, according to a new study. Excessive daytime napping might thusContinue reading “Alzheimer’s Directly Kills Brain Cells That Keep You Awake”

Low-carb ‘keto’ diet (‘Atkins-style’) may modestly improve cognition in older adults

In a pilot study of 14 older adults with mild cognitive problems suggestive of early Alzheimer’s disease, Johns Hopkins Medicine researchers report that a high-fat, low-carbohydrate diet may improve brain function and memory. Although the researchers say that finding participants willing to undertake restrictive diets for the three-month study—or partners willing to help them stickContinue reading “Low-carb ‘keto’ diet (‘Atkins-style’) may modestly improve cognition in older adults”

A newly identified type of dementia that is sometimes mistaken for Alzheimer’s disease

Doctors have newly outlined a type of dementia that could be more common than Alzheimer’s among the oldest adults, according to a report published Tuesday in the journal Brain. The disease, called LATE, may often mirror the symptoms of Alzheimer’s disease, though it affects the brain differently and develops more slowly than Alzheimer’s. Doctors sayContinue reading “A newly identified type of dementia that is sometimes mistaken for Alzheimer’s disease”

A Dozen Dolphins Have Beached Themselves, Showing The Deadly Hallmark of Alzheimer’s disease

by Carly Cassella Over a dozen dolphins, stranded on the beaches of Florida and Massachusetts, have been found with brains full of amyloid plaques, a hallmark of Alzheimer’s disease. The scientists who made the discovery think it may be a warning to us all: alongside the Alzheimer’s-like plaques, the team also found the environmental toxinContinue reading “A Dozen Dolphins Have Beached Themselves, Showing The Deadly Hallmark of Alzheimer’s disease”