Organic printing inks may restore sight to blind people

An array of semitransparent organic pixels on top of a ultrathin sheet of gold. The thickness of both the organic islands and the underlying gold is more than one-hundred times thinner than a single neuron.

SUMMARY: A simple retinal prosthesis is under development. Fabricated using cheap and widely-available organic pigments used in printing inks and cosmetics, it consists of tiny pixels like a digital camera sensor on a nanometric scale. Researchers hope that it can restore sight to blind people.

Researchers led by Eric Glowacki, principal investigator of the organic nanocrystals subgroup in the Laboratory of Organic Electronics, Linköping University, have developed a tiny, simple photoactive film that converts light impulses into electrical signals. These signals in turn stimulate neurons (nerve cells). The research group has chosen to focus on a particularly pressing application, artificial retinas that may in the future restore sight to blind people. The Swedish team, specializing in nanomaterials and electronic devices, worked together with researchers in Israel, Italy and Austria to optimise the technology. Experiments in vision restoration were carried out by the group of Yael Hanein at Tel Aviv University in Israel. Yael Hanein’s group is a world-leader in the interface between electronics and the nervous system.

The results have recently been published in the scientific journal Advanced Materials.

The retina consists of several thin layers of cells. Light-sensitive neurons in the back of the eye convert incident light to electric signals, while other cells process the nerve impulses and transmit them onwards along the optic nerve to an area of the brain known as the “visual cortex.” An artificial retina may be surgically implanted into the eye if a person’s sight has been lost as a consequence of the light-sensitive cells becoming degraded, thus failing to convert light into electric pulses.

The artificial retina consists of a thin circular film of photoactive material, and is similar to an individual pixel in a digital camera sensor. Each pixel is truly microscopic — it is about 100 times thinner than a single cell and has a diameter smaller than the diameter of a human hair. It consists of a pigment of semi-conducting nanocrystals. Such pigments are cheap and non-toxic, and are commonly used in commercial cosmetics and tattooing ink.

“We have optimised the photoactive film for near-infrared light, since biological tissues, such as bone, blood and skin, are most transparent at these wavelengths. This raises the possibility of other applications in humans in the future,” says Eric Glowacki.

He describes the artificial retina as a microscopic doughnut, with the crystal-containing pigment in the middle and a tiny metal ring around it. It acts without any external connectors, and the nerve cells are activated without a delay.

“The response time must be short if we are to gain control of the stimulation of nerve cells,” says David Rand, postdoctoral researcher at Tel Aviv University. “Here, the nerve cells are activated directly. We have shown that our device can be used to stimulate not only neurons in the brain but also neurons in non-functioning retinas.”

Smartphone Blindness

A short-lived optical sensation can lead some smartphone users to mistakenly believe they’ve lost sight in one eye, according to a research letter published in the June 23 issue of the New England Journal of Medicine.

The letter cites two case studies: a 22-year-old woman who’d suffered recurring bouts of nighttime vision loss in her right eye for several months, and a 40-year-old woman who would wake up with a loss of vision in one eye that lasted as long as 15 minutes.

Both women underwent several tests, including magnetic resonance imaging and echocardiograms, before doctors realized that the transient “blindness” was due to an optical adaptation of the eyes caused by reading a smartphone in the dark while lying on their side in bed. When one eye was occluded by the pillow and they were viewing the phone with the other eye, the occluded eye adapted to the dark and the viewing eye adapted to the light. When both eyes were uncovered in the dark, the light-adapted eye was perceived to be “blind,” an effect lasting several minutes.

“I have seen a dozen or so similar cases,” study author Gordon Plant, M.D. an ophthalmologist with Moorfields Eye Hospital in London, told HealthDay. “The reason I wish to make this known is because it leads to anxiety and unnecessary investigation because the patients — and their doctors — think they have had a transient ischemic attack.”